Oxycodone and acetaminophen combination is used to relieve moderate to moderately severe pain.

Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. But acetaminophen may cause other unwanted effects when taken in large doses, including liver damage.

Oxycodone belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain.

When oxycodone is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

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  • Endocet, Magnacet, Narvox, Percocet, Perloxx, Primalev
  • More common
    Abdominal or stomach pain
    black, tarry stools
    chills
    dark urine
    dizziness
    fever
    headache
    itching
    light-colored stools
    loss of appetite
    nausea
    rash
    unpleasant breath odor
    unusual tiredness or weakness
    vomiting of blood
    yellow eyes or skin
    Rare
    Cough or hoarseness
    fever with or without chills
    general feeling of tiredness or weakness
    lower back or side pain
    painful or difficult urination
    sore throat
    sores, ulcers, or white spots on the lips or in the mouth
    unusual bleeding or bruising
    Incidence not known
    Back, leg, or stomach pains
    bleeding gums
    bloating
    blood in the urine or stools
    blue lips and fingernails
    blurred vision
    burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    chest pain or discomfort
    clay-colored stools
    cloudy urine
    clumsiness
    confusion
    constipation
    coughing that sometimes produces a pink frothy sputum
    decrease in the frequency of urination
    decrease in urine volume
    decreased awareness or responsiveness
    decreased frequency or amount of urine
    decreased urination
    difficult or labored breathing
    difficult or painful urination
    difficult, fast, noisy breathing, sometimes with wheezing
    difficulty in passing urine (dribbling)
    difficulty with swallowing
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    drowsiness
    dry mouth
    extremely shallow or slow breathing
    fainting
    fast or deep breathing
    fast, slow, irregular, pounding, or racing heartbeat or pulse
    feeling of warmth
    general body swelling
    greatly decreased frequency of urination or amount of urine
    increased sweating
    increased thirst
    indigestion
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    lightheadedness
    muscle aches
    muscle tremors
    muscle weakness
    nervousness
    noisy breathing
    nosebleeds
    numbness or tingling in the hands, feet, or lips
    pains in the stomach, side, or abdomen, possibly radiating to the back
    pale skin
    pinpoint red spots on the skin
    pounding in the ears
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    rapid, deep breathing
    rapid, shallow breathing
    redness of the face, neck, arms, and occasionally, upper chest
    redness of the skin
    restlessness
    seizures
    severe constipation
    severe sleepiness
    severe vomiting
    shivering
    skin blisters
    skin rash, hives, or welts
    sleepiness
    slow or irregular breathing
    sore throat
    stomach cramps
    stomach pain, continuing
    sudden decrease in the amount of urine
    sunken eyes
    sweating
    swelling in the legs and ankles
    swelling of the face, fingers, or lower legs
    thirst
    tightness in the chest
    tiredness
    troubled breathing
    unpleasant breath odor
    upper right abdominal or stomach pain
    vomiting
    weak or feeble pulse
    weakness or heaviness of the legs
    weight gain
    wrinkled skin
    Get emergency help immediately if any of the following symptoms of overdose occur:

    Symptoms of overdose
    Bluish lips or skin
    change in consciousness
    cold, clammy skin
    extreme sleepiness
    general feeling of discomfort or illness
    loss of consciousness
    no blood pressure or pulse
    not breathing
    stopping of heart
    unconsciousness
    Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    More common
    Relaxed and calm
    Incidence not known
    Acid or sour stomach
    agitation
    bad or unusual or unpleasant (after) taste
    belching
    change in taste
    cold sweats
    constricted, pinpoint, or small pupils (black part of the eye)
    continuing ringing or buzzing or other unexplained noise in the ears
    cool, pale skin
    depression
    diarrhea
    difficulty with moving
    disturbed color perception
    double vision
    excess air or gas in the stomach or intestines
    false or unusual sense of well-being
    flushed, dry skin
    fruit-like breath odor
    full feeling
    general feeling of discomfort or illness
    halos around lights
    hearing loss
    heartburn
    increased hunger
    increased thirst
    increased urination
    indigestion
    joint pain
    lack or loss of strength
    muscle cramps or spasms
    muscle pain or stiffness
    night blindness
    nightmares
    overbright appearance of lights
    passing gas
    red eye
    seeing, hearing, or feeling things that are not there
    seizures
    shakiness
    sleepiness or unusual drowsiness
    slurred speech
    stomach discomfort, upset, or pain
    stomach fullness
    sweating
    swollen joints
    thirst
    trouble sleeping
    tunnel vision
    unexplained weight loss
    unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  • The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For moderate to moderately severe pain: For oral dosage form (capsules): Adults—1 capsule every 6 hours as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—2 tablets every 12 hours as needed. The second dose may be given as early as 8 hours after your first dose, and the following doses are given every 12 hours. Children—Use and dose must be determined by your doctor. For oral dosage form (solution): Adults—5 milliliters (mL) or one teaspoonful every 6 hours as needed. Your doctor may increase your dose as needed. However, the dose is usually not more than 60 mL (12 teaspoonfuls) per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—1 tablet every 6 hours as needed. Children—Use and dose must be determined by your doctor.