Lotrel contains a combination of amlodipine and benazepril. Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow.

Benazepril is an antihypertensive. ACE stands for angiotensin converting enzyme. Benazeprilconjointly widens blood vessels and conjointly prevents the body from retentive water.

Lotrel is employed to treat high pressure (hypertension).

Lotrel might also be used for functions ex-directory during this medication guide.

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  • Lotrel
  • Applies to amlodipine / benazepril: oral capsule

    In addition to its needed effects, some unwanted effects may be caused by amlodipine / benazepril. In the event that any of these side effects do occur, they may require medical attention.

    You should check with your doctor immediately if any of these side effects occur when taking amlodipine / benazepril:

    Less common
    Confusion
    dizziness, lightheadedness, or fainting
    fast or irregular heartbeat
    nervousness
    numbness or tingling in the hands, feet, or lips
    shortness of breath
    swelling of the ankles, feet, or lower legs
    weakness or heaviness of the legs
    Rare
    Bleeding gums
    chills
    fever
    nausea or vomiting
    nosebleeds
    pale skin
    sores, ulcers, or white spots on the lips, tongue, or inside the mouth
    stomach pain or bloating with fever, nausea, or vomiting
    swelling of the face, mouth, hands, or feet
    trouble with swallowing or breathing (sudden) or hoarseness
    unusual bleeding or bruising
    unusual tiredness or weakness
    yellow eyes or skin
    Incidence not known
    Chest pain
    heartburn
    pain or burning in the throat
    Some of the side effects that can occur with amlodipine / benazepril may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Less common
    Cough (dry and continues)
    feeling of warmth
    redness of the face, neck, arms, and occasionally upper chest
    sleepiness
    Incidence not known
    Acid or sour stomach
    belching
    blistering, crusting, irritation, itching, or reddening of the skin
    body aches or pain
    cracked, dry, or scaly skin
    decreased interest in sexual intercourse
    difficulty having a bowel movement (stool)
    frequent urination
    inability to have or keep an erection
    increased volume of pale, dilute urine
    indigestion
    lack or loss of strength
    loss in sexual ability, desire, drive, or performance
    muscle or bone pain
    shakiness in the legs, arms, hands, or feet
    stomach discomfort or upset
    sudden sweating
    swelling
    tender, swollen glands in the neck
    trembling or shaking of the hands or feet
    trouble with sleeping
    voice changes
  • The recommended initial dose of Lotrel is 1 capsule of amlodipine 2.5 mg/benazepril 10 mg orally once-daily. It is usually appropriate to begin therapy with Lotrel only after a patient has either (a) failed to achieve the desired antihypertensive effect with amlodipine or benazepril monotherapy, or (b) demonstrated inability to achieve adequate antihypertensive effect with amlodipine therapy without developing edema. The antihypertensive effect of Lotrel is largely attained within 2 weeks. If blood pressure remains uncontrolled, the dose may be titrated up to amlodipine 10 mg/benazepril 40 mg once-daily. The dosing should be individualized and adjusted according to the patient’s clinical response. Amlodipine is an effective treatment of hypertension in once-daily doses of 2.5 to 10 mg while benazepril is effective in doses of 10 to 80 mg. In clinical trials of amlodipine/benazepril combination therapy using amlodipine doses of 2.5 to 10 mg and benazepril doses of 10 to 40 mg, the antihypertensive effects increased with increasing dose of amlodipine in all patient groups, and the effects increased with increasing dose of benazepril in nonblack groups.