Lotrel contains a combination of amlodipine and benazepril. Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow.
Benazepril is an antihypertensive. ACE stands for angiotensin converting enzyme. Benazeprilconjointly widens blood vessels and conjointly prevents the body from retentive water.
Lotrel is employed to treat high pressure (hypertension).
Lotrel might also be used for functions ex-directory during this medication guide.
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Applies to amlodipine / benazepril: oral capsule
In addition to its needed effects, some unwanted effects may be caused by amlodipine / benazepril. In the event that any of these side effects do occur, they may require medical attention.
You should check with your doctor immediately if any of these side effects occur when taking amlodipine / benazepril:
dizziness, lightheadedness, or fainting
fast or irregular heartbeat
numbness or tingling in the hands, feet, or lips
shortness of breath
swelling of the ankles, feet, or lower legs
weakness or heaviness of the legs
nausea or vomiting
sores, ulcers, or white spots on the lips, tongue, or inside the mouth
stomach pain or bloating with fever, nausea, or vomiting
swelling of the face, mouth, hands, or feet
trouble with swallowing or breathing (sudden) or hoarseness
unusual bleeding or bruising
unusual tiredness or weakness
yellow eyes or skin
Incidence not known
pain or burning in the throat
Some of the side effects that can occur with amlodipine / benazepril may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Cough (dry and continues)
feeling of warmth
redness of the face, neck, arms, and occasionally upper chest
Incidence not known
Acid or sour stomach
blistering, crusting, irritation, itching, or reddening of the skin
body aches or pain
cracked, dry, or scaly skin
decreased interest in sexual intercourse
difficulty having a bowel movement (stool)
inability to have or keep an erection
increased volume of pale, dilute urine
lack or loss of strength
loss in sexual ability, desire, drive, or performance
muscle or bone pain
shakiness in the legs, arms, hands, or feet
stomach discomfort or upset
tender, swollen glands in the neck
trembling or shaking of the hands or feet
trouble with sleeping
The recommended initial dose of Lotrel is 1 capsule of amlodipine 2.5 mg/benazepril 10 mg orally once-daily. It is usually appropriate to begin therapy with Lotrel only after a patient has either (a) failed to achieve the desired antihypertensive effect with amlodipine or benazepril monotherapy, or (b) demonstrated inability to achieve adequate antihypertensive effect with amlodipine therapy without developing edema. The antihypertensive effect of Lotrel is largely attained within 2 weeks. If blood pressure remains uncontrolled, the dose may be titrated up to amlodipine 10 mg/benazepril 40 mg once-daily. The dosing should be individualized and adjusted according to the patient’s clinical response. Amlodipine is an effective treatment of hypertension in once-daily doses of 2.5 to 10 mg while benazepril is effective in doses of 10 to 80 mg. In clinical trials of amlodipine/benazepril combination therapy using amlodipine doses of 2.5 to 10 mg and benazepril doses of 10 to 40 mg, the antihypertensive effects increased with increasing dose of amlodipine in all patient groups, and the effects increased with increasing dose of benazepril in nonblack groups.