Lorazepam belongs to a group of drugs called benzodiazepines. It affects chemicals in the brain that may be unbalanced in people with anxiety. It is usually prescribed to treat anxiety disorders. The injection is indicated in adult patients for preanesthetic medication, producing sedation (sleepiness or drowsiness), relief of anxiety, and a decreased ability to recall events related to the day of surgery. It is most useful in those patients who are anxious about their surgical procedure and who would prefer to have diminished recall of the events of the day of surgery
You should not use lorazepam if you have narrow-angle glaucoma or myasthenia gravis, or if you are allergic to Valium or a similar medicine. Also, do not use lorazepam if you are pregnant. This medication can cause birth defects or life-threatening withdrawal symptoms in a newborn.
Lorazepam may be habit-forming and should be used only by the person it was prescribed for. This medicine should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.
Avoid using other medicines that make you sleepy. They can add to sleepiness caused by lorazepam.
Do not drink alcohol while taking lorazepam. This medication can increase the effects of alcohol.
The adverse clinical events most commonly observed with the use of Lorazepam Injection in clinical trials evaluating its use in status epilepticus were hypotension, somnolence, and respiratory failure.
For the primary purpose of sedation and relief of anxiety, the usual recommended initial dose of lorazepam for intravenous injection is 2 mg total, or 0.02 mg/lb (0.044 mg/kg), whichever is smaller.