Serious and sometimes fatal rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis, have rarely occurred with the use of lamotrigine. The risk of serious rash may be greater in children younger than 16 years old than in adults. Although it has not been proven, the risk may also be greater if you start taking lamotrigine at a higher dose than recommended, if you take more than the recommended dose during treatment, or if you also take a medicine called valproate (eg, valproic acid, divalproex sodium). Most of the serious rashes that have occurred with the use of lamotrigine developed within the first 2 to 8 weeks of treatment. However, serious rashes have also occurred in patients who have used lamotrigine for a longer period of time. Contact your doctor at once if you develop rash symptoms, including red, swollen, blistered, or peeling skin. Treatment with lamotrigine should be stopped if rash occurs, unless it is clearly determined that the medicine did not cause the rash. Even if lamotrigine is stopped, a rash caused by lamotrigine may still become life-threatening or cause other serious side effects (eg, permanent scarring).

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  • Lamotrigine
  • Commonly reported side effects of lamotrigine include diplopia, insomnia, rhinitis, dizziness, headache, drowsiness, tremor, blurred vision, skin rash, nausea, ataxia, vomiting, abdominal pain, and fever. Other side effects include vaginitis, dyspepsia, dysmenorrhea, pruritus, bronchitis, weakness, abnormal gait, pain, constipation, and emotional lability. See below for a comprehensive list of adverse effects.
  • General dosage information for: Lamotrigine (oral tablet, oral tablet, dispersible, oral tablet, disintegrating, oral tablet, extended release) Please confirm that the medication forms on the dosage document(s) above are relevant for the specific drug you are interested in.