Acetaminophen is a pain reliever and fever reducer.

Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Acetaminophen, chlorpheniramine, and pseudoephedrine is a combination medicine used to treat headache, fever, body aches, runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

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  • Alka-Seltzer Plus Cold Liquigel, Comtrex Allergy Sinus, Comtrex Allergy Sinus Maximum Strength, Kolephrin, Sinutab Ex-Strength, Theraflu Maximum Strength
  • Stop using this medicine and call your doctor at once if you have:

    chest pain, rapid pulse, fast or uneven heart rate;
    confusion, hallucinations, severe nervousness;
    tremor, seizure (convulsions);
    easy bruising or bleeding, unusual weakness;
    little or no urinating;
    nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of your skin or eyes); or
    dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, shortness of breath, uneven heartbeats, seizure).
    Side effects such as dry mouth, constipation, and confusion may be more likely in older adults.

    Common side effects may include:

    dizziness, drowsiness;
    mild headache, blurred vision;
    dry mouth, nose, or throat;
    constipation;
    feeling nervous; or
    sleep problems (insomnia).
  • Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. This medicine is usually taken only for a short time until your symptoms clear up. Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Dissolve one packet of the powder in at least 4 ounces of water. Stir this mixture and drink all of it right away. Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not take for longer than 7 days in a row. Call your doctor if your symptoms do not improve after 7 days of treatment, if you still have a fever after 3 days, or if you have a fever with a headache, cough, or skin rash. If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days.