Glucarpidase is used in patients who develop kidney failure while receiving high doses of methotrexate (a chemotherapy drug).

Glucarpidase is an enzyme that breaks down methotrexate in the body so the drug can be easily eliminated when the kidneys are not working properly.

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  • Voraxaze
  • Less common
    Blurred vision
    confusion
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    sweating
    unusual tiredness or weakness
    Rare
    Cough
    difficulty with swallowing
    dizziness
    fever
    headache
    hives
    hoarseness
    irritation
    itching
    joint pain, stiffness, or swelling
    nervousness
    pounding in the ears
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    rash
    redness of the skin
    shortness of breath
    slow or fast heartbeat
    swelling of the eyelids, face, lips, hands, or feet
    tightness in the chest
    troubled breathing or swallowing
    wheezing
    Some of the side effects that can occur with glucarpidase may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Less common
    Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    feeling of warmth
    nausea
    redness of the face, neck, arms, and occasionally, upper chest
    vomiting
    Rare
    Diarrhea
    shakiness in the legs, arms, hands, or feet
    sore throat
    trembling or shaking of the hands or feet
  • (intravenous powder for injection)