Exparel (bupivacaine) is an anesthetic (numbing medicine) that blocks nerve impulses in your body.

Exparel is employed as an area (in only 1 area) anesthetic to numb a neighborhood of your body for a surgical process like lump removal or haemorrhoid surgery.

Exparel might also be used for functions unlisted during this medication guide.

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  • Exparel
  • Get emergency medical help if you have signs of an allergic reaction to Exparel: hives, red rash, itching; sneezing, difficulty breathing; severe dizziness, vomiting; swelling of your face, lips, tongue, or throat.

    You will be watched closely after receiving Exparel, to make sure you do not have a reaction to the medicine. Tell your caregivers at once if you have any of these signs of a serious side effect:

    ringing in your ears;
    feeling restless or anxious;
    feeling like you might pass out;
    speech or vision problems, a metallic taste in your mouth;
    numbness or tingling around your mouth;
    tremors, twitching, mood changes;
    fast heart rate, feeling short of breath, feeling unusually hot or cold;
    numbness, weakness, or loss of movement where the injection was given; or
    if you still feel numb several hours after your surgery.
    Common Exparel side effects include:

    nausea;
    vomiting; or
    constipation.
  • Exparel is intended for single-dose administration only for post surgical analgesia. The recommended dose of Exparel is based on the surgical site and the volume required to cover the area: Bunionectomy: 7 mL infiltrated into the tissues surrounding the osteotomy and 1 mL into the subcutaneous tissue. Hemorrhoidectomy: Dilute 20 mL of Exparel with 10 mL of saline, for a total of 30 mL, and divide the mixture into six 5 mL aliquots. Perform the anal block by visualizing the anal sphincter as a clock face and slowly infiltrating one aliquot to each of the even numbers.