Acetaminophen is a pain reliever and a fever reducer.

Diphenhydramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Acetaminophen and diphenhydramine is a combination medicine used to treat headache, runny nose, sneezing, watery eyes, and pain or fever caused by allergies, the common cold, or the flu.

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  • Aceta-Gesic, Coricidin Night Time Cold Relief, Excedrin PM, Headache Relief PM, Legatrin PM, Mapap PM, Midol PM, Night Time Pain, Pain Relief PM Extra Strength, Percogesic Extra Strength, Tylenol Cold Relief Nighttime, Tylenol PM, Tylenol Sore Throat Nighttime, Unisom with Pain Relief
  • Stop using the medicine and call your doctor at once if you have:

    fast, pounding, or uneven heartbeats;
    severe dizziness or drowsiness, slow or shallow breathing;
    tremor, restless muscle movements;
    little or no urinating;
    flu symptoms, easy bruising, unusual bleeding, pale skin, feeling light-headed; or
    nausea, pain in your upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
    Common side effects may include:

    constipation;
    dry eyes, blurred vision, dry mouth or nose;
    mild dizziness or drowsiness, trouble concentrating;
    feeling restless or excited (especially in children); or
    mild skin rash.
  • Usual Adult Dose for Insomnia Note: Acetaminophen-diphenhydramine is generally dosed based on the diphenhydramine component to equal 50 mg of diphenhydramine (76 mg diphenhydramine citrate) at bedtime. Acetaminophen-diphenhydramine comes in several different dosages (500 mg-25 mg, 650 mg-50 mg, 500 mg-38 mg, 500 mg-12.5 mg, 1000 mg-50 mg, 500 mg-50 mg, 325 mg-12.5 mg) and is available as liquid, caplets, geltabs, and gelcaps. The manufacturer of these products generally advises 2 dosage units at bedtime or as directed by a healthcare professional.