Amifostine a chemoprotectant (KEEM-o-pro-TEK-tant) that can help lessen the side effects of certain cancer chemotherapy medications or radiation treatment.

Amifostine is used to protect the kidneys from harmful effects caused by cisplatin when given to patients with ovarian cancer.

Amifostine is also used to prevent severe dry mouth caused by radiation treatment of the head and neck, which can affect the salivary gland.

Amifostine will not prevent all side effects of chemotherapy medications. However, this medication may help protect your body from some of the serious side effects that chemotherapy can cause.

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  • Ethyol
  • More common
    Blurred vision
    confusion
    dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
    fainting or loss of consciousness
    fast or irregular breathing
    itching
    nausea and vomiting
    red, scaly, swollen, or peeling areas of the skin
    skin rash
    sweating
    swelling of the eyes or eyelids
    tightness in the chest
    trouble with breathing
    unusual tiredness or weakness
    wheezing
    Rare
    Abdominal cramps
    blistering, peeling, or loosening of the skin
    burning or tingling sensation
    chills
    convulsions
    cough
    cracks in the skin
    diarrhea
    difficulty in breathing
    fast, slow, or irregular heartbeat or pulse
    fever
    joint or muscle pain
    loss of bladder control
    loss of heat from the body
    muscle cramps in the hands, arms, feet, legs, or face
    muscle spasm or jerking of all extremities
    no blood pressure or pulse
    numbness and tingling around the mouth, fingertips, or feet
    palpitations
    red irritated eyes
    red skin lesions, often with a purple center
    shortness of breath
    sore throat
    sores, ulcers, or white spots in the mouth or on the lips
    stopping of the heart
    sudden loss of consciousness
    tremor
    unconsciousness
    Incidence not known
    Difficulty in swallowing
    hives or welts
    hoarseness
    slow or irregular breathing
    Some of the side effects that can occur with amifostine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Less common or rare
    Feeling unusually warm or cold
    flushing or redness of the face or neck
    headache
    hiccups
    nervousness
    pounding in the ears
    sleepiness (severe)
    sneezing
  • (amifostine) for Injection