Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may be unbalanced in people with depression.

Duloxetine is used to treat major depressive disorder in adults. Duloxetine is also used to treat general anxiety disorder in adults and children who are at least 7 years old.

Duloxetine is also used in adults to treat fibromyalgia (a chronic pain disorder), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain).

Duloxetine is also used to treat pain caused by nerve damage in adults with diabetes (diabetic neuropathy).

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  • Cymbalta, Irenka
  • Incidence not known
    Abdominal or stomach pain
    area rash
    blistering, peeling, or loosening of the skin
    blurred vision
    change in consciousness
    clay-colored stools
    cold sweats
    dark urine
    decreased urine output
    decreased vision
    difficulty swallowing
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    eye pain
    fast or irregular heartbeat
    general tiredness or weakness
    hives or welts, itching, or skin rash
    hives, itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
    increased thirst
    joint or muscle pain
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    light-colored stools
    loss of consciousness
    red skin lesions, often with a purple center
    red, irritated eyes
    redness of the skin
    sores, ulcers, or white spots in the mouth or on the lips
    swelling of the face, ankles, or hands
    tightness in the chest
    unpleasant breath odor
    upper right stomach pain
    vomiting of blood
    yellow eyes and skin
    If any of the following symptoms of overdose occur while taking duloxetine, get emergency help immediately:

    Symptoms of overdose
    loss of bladder control
    muscle spasm or jerking of all extremities
    overactive reflexes
    poor coordination
    sleepiness or unusual drowsiness
    sudden loss of consciousness
    talking or acting with excitement you cannot control
    trembling or shaking
    unusual tiredness or weakness
    Severity: Minor
    Some of the side effects that can occur with duloxetine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Body aches or pain
    difficulty having a bowel movement (stool)
    dry mouth
    ear congestion
    frequent urination
    lack or loss of strength
    loss of appetite
    loss of voice
    muscle aches
    sleepiness or unusual drowsiness
    sore throat
    stuffy or runny nose
    sweating increased
    trouble sleeping
    weight loss
    Less common
    Abnormal orgasm
    acid or sour stomach
    burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    change in taste
    change or problem with discharge of semen
    decreased interest in sexual intercourse
    difficulty with moving
    feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest
    inability to have or keep an erection
    joint pain
    longer than usual time to ejaculation of semen
    loose stools
    loss in sexual ability, desire, drive, or performance
    loss of taste
    muscle aching or cramping
    muscle pains or stiffness
    shakiness in the legs, arms, hands, or feet
    stomach discomfort or upset
    sudden sweating
    swollen joints
    trembling or shaking of the hands or feet
  • (oral delayed release capsule)