This medication guide provides information about the use of doxepin (Sinequan or other generic names) to treat depression or anxiety. Silenor is another brand of doxepin that is not covered in this medication guide.

Doxepin is a tricyclic antidepressant. Doxepin affects chemicals in the brain that may become unbalanced.

Doxepin (Sinequan or other generic name) is used to treat symptoms of depression and/or anxiety associated with alcoholism, psychiatric conditions, or manic-depressive conditions.

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  • SINEquan
  • Incidence not known
    Abdominal or stomach pain
    black, tarry stools
    bleeding gums
    blood in the urine or stools
    blurred vision
    burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    canker sores
    chest pain
    clay-colored stools
    cold sweats
    confusion about identity, place, and time
    cool, pale skin
    cough or hoarseness
    dark urine
    decrease in the frequency of urination
    decrease in urine volume
    decreased urine output
    difficulty in passing urine (dribbling)
    difficulty with breathing
    difficulty with speaking
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    dry mouth
    fast, pounding, or irregular heartbeat or pulse
    feeling of warmth
    flushed, dry skin
    fruit-like breath odor
    general feeling of tiredness or weakness
    hearing loss
    increased hunger
    increased thirst
    increased urination
    itching or rash
    lip smacking or puckering
    loss of appetite
    loss of balance control
    loss of bladder control
    lower back or side pain
    mood or mental changes
    muscle spasm or jerking of all extremities
    muscle trembling, jerking, or stiffness
    muscle twitching
    noisy breathing
    painful or difficult urination
    pinpoint red spots on the skin
    pounding in the ears
    puffing of the cheeks
    rapid or worm-like movements of the tongue
    rapid weight gain
    redness of the face, neck, arms, and occasionally, upper chest
    ringing or buzzing or other unexplained noise in the ears that continues
    seeing, hearing, or feeling things that are not there
    shakiness and unsteady walk
    shakiness in the legs, arms, hands, or feet
    shuffling walk
    sore throat
    sores, ulcers, or white spots on the lips, tongue, or in the mouth
    slurred speech
    stiffness of the limbs
    sudden loss of consciousness
    swelling of the face, ankles, or hands
    swollen glands
    tightness in the chest
    troubled breathing
    twisting movements of the body
    uncontrolled chewing movements
    uncontrolled movements, especially of the arms, face, legs, neck, and back
    unexplained weight loss
    unpleasant breath odor
    unsteadiness, trembling, or other problems with muscle control or coordination
    unusual bleeding or bruising
    unusual tiredness or weakness
    vomiting of blood
    yellow eyes or skin
    If any of the following symptoms of overdose occur while taking doxepin, get emergency help immediately:

    Symptoms of overdose
    disturbed concentration
    enlarged pupils
    increased or excessive unconscious or jerking movements
    low body temperature
    muscle aches
    muscle weakness
    weak or feeble pulse
    weight gain
    Severity: Minor
    Some of the side effects that can occur with doxepin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Incidence not known
    Change in taste or bad, unusual or unpleasant (after) taste
    decreased interest in sexual intercourse
    difficulty having a bowel movement (stool)
    enlargement of the breasts
    gas in the stomach
    hair loss or thinning of the hair
    inability to have or keep an erection
    increased in sexual ability, desire, drive, or performance
    increased interest in sexual intercourse
    increased sensitivity of the skin to sunlight
    loss in sexual ability, desire, drive, or performance
    redness or other discoloration of the skin
    severe sunburn
    swelling of the breasts or breast soreness in both females and males
    swelling of the testicles
    unexpected or excess milk flow from breasts
    weight loss
  • (oral concentrate, oral capsule, oral tablet)