Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Diphenhydramine is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.

Diphenhydramine is also used to treat motion sickness, to induce sleep, and to treat certain symptoms of Parkinson’s disease.

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  • Allergy Relief (Diphenhydramine HCl), Allermax, Banophen, Benadryl, Compoz Nighttime Sleep Aid, Diphedryl, Diphenhist, Dytuss, Nytol QuickCaps, PediaCare Children's Allergy, Scot-Tussin Allergy Relief Formula, Silphen Cough, Simply Sleep, Sleepinal, Sominex, Theraflu Thin Strips Multi Symptom, Tranquil, Triaminic Thin Strips Allergy, Twilite, Unisom Sleepgels Maximum Strength, Valu-Dryl, Z-Sleep, ZzzQuil
  • Stop using diphenhydramine and call your doctor at once if you have:

    pounding heartbeats or fluttering in your chest;
    painful or difficult urination;
    little or no urinating;
    confusion, feeling like you might pass out; or
    tightness in your neck or jaw, uncontrollable movements of your tongue.
    Common side effects may include:

    dizziness, drowsiness, loss of coordination;
    dry mouth, nose, or throat;
    constipation, upset stomach;
    dry eyes, blurred vision; or
    day-time drowsiness or "hangover" feeling after night-time use.
  • Usual Pediatric Dose for Allergic Rhinitis Greater than or equal to 2 to less than 6 years: 6.25 mg orally every 4 to 6 hours, not to exceed 37.5 mg/24 hours. Greater than or equal to 6 to less than 12 years: 12.5 to 25 mg orally every 4 to 6 hours, not to exceed 150 mg/24 hours. Greater than or equal to 12 years: 25 to 50 mg orally every 4 to 6 hours, not to exceed 300 mg/24 hours.