Differin (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. It helps the skin to renew itself.

Differin is used to treat severe acne in people who are at least 12 years old. It works by decreasing acne formation.

Differin may also be used for purposes other than those listed in this medication guide.

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  • Differin cream, gel, lotion
  • For the Consumer

    Applies to adapalene topical: topical cream, topical gel/jelly, topical lotion, topical solution, topical swab

    In addition to its needed effects, some unwanted effects may be caused by adapalene topical (the active ingredient contained in Differin). In the event that any of these side effects do occur, they may require medical attention.

    If any of the following side effects occur while taking adapalene topical, check with your doctor or nurse as soon as possible:

    More common - especially during the first month of use
    Burning sensation or stinging of skin
    dryness and peeling of skin
    itching of skin
    redness of skin
    Some of the side effects that can occur with adapalene topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Rare - more common during the first month of use
    Worsening of acne
  • Differin (adapalene) gel Differin Cream (adapalene) cream Differin Lotion (adapalene) lotion General dosage information for the active ingredient contained in Differin: Adapalene Topical (topical gel, topical cream, topical swab, topical solution, topical lotion) Please confirm that the medication forms on the dosage document(s) above are relevant for the specific drug you are interested in.
  • Acne

    Minocycline is a tetracycline antibiotic that fights bacteria in the body. Minocycline is used to treat many different bacterial infections, such as urinary tract infections, respiratory infections, skin infections, severe acne, gonorrhea, tick fever, chlamydia, and others. Minocycline may also be used for purposes not listed in this medication guide.