Treating joint swelling, pain, and stiffness caused by osteoarthritis or rheumatoid arthritis in patients who are at a high risk of developing NSAID-induced ulcers or their complications. It may also be used for other conditions as determined by your doctor.

Diclofenac/misoprostol is an NSAID and prostaglandin analog combination. The prostaglandin maintains prostaglandin activity needed to protect the lining of the stomach and reduce acid secretion, reducing the risk of ulcers. The NSAID decreases prostaglandins that cause pain and inflammation, relieving joint pain.

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  • Arthrotec
  • Less common
    Black, tarry stools
    bleeding or crusting sores on the lips
    blood in the urine or stools
    bruises or red spots on the skin
    chest pain
    chills
    confusion
    continuing thirst
    convulsions (seizures)
    cough or hoarseness
    disorientation
    drowsiness
    fainting
    fever with or without chills
    fluid retention
    general feeling of illness
    heartburn or indigestion
    increased heart rate
    increased weight gain
    irregular heartbeat
    itching of the skin
    large, flat, blue or purplish patches on the skin
    lightheadedness or dizziness
    lower back or side pain
    mental depression
    muscle cramps
    nausea
    painful or difficult urination
    pounding heartbeat
    psychotic reaction
    rectal bleeding
    seeing, hearing, or feeling things that are not there
    severe headache
    severe liver reactions
    severe stomach pain, cramping, or burning
    skin rash
    sore throat
    sores, ulcers, or white spots on the lips or in the mouth
    stiff neck or back
    sudden decrease in the amount of urine
    swelling or tenderness in the upper stomach
    swelling of the face, fingers, feet, or lower legs
    troubled breathing, tightness in the chest
    unusual bleeding or bruising
    unusual tiredness or weakness
    vomiting of material that looks like coffee grounds
    yellow eyes or skin
    Rare
    Changes in facial skin color
    fast or irregular breathing
    puffiness or swelling of the eyelids or around the eyes
    If any of the following symptoms of overdose occur while taking diclofenac / misoprostol, get emergency help immediately:

    Symptoms of overdose
    Diarrhea
    fever
    slow heartbeat
    stomach pain
    trembling or shaking
  • (oral tablet)