Diazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Diazepam affects chemicals in the brain that may be unbalanced in people with seizures.

Diazepam rectal (for use in the rectum) is used to treat occasionally increased seizures (cluster seizures) in people with epilepsy who also routinely take other anti-convulsants. Diazepam rectal is not for long-term daily use to prevent seizures.

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  • Diastat AcuDial, Diastat Pediatric
  • Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

    Call your doctor at once if the person receiving this medication has:

    worsening seizures, or seizures that seem different from the patient's other seizures;
    pale or discolored skin, feeling like you might pass out;
    confusion, hallucinations, unusual thoughts or behavior, unusual risk-taking behavior, decreased inhibitions, no fear of danger; or
    hyperactivity, agitation, hostility, depressed mood, thoughts of suicide or hurting yourself.
    The sedative effects of diazepam rectal may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are using diazepam rectal.

    Common side effects may include:

    drowsiness, dizziness, headache, nervous feeling;
    stomach pain, diarrhea;
    flushing (warmth, redness, or tingly feeling);
    weakness, loss of coordination; or
    runny nose, sneezing.
  • The rectal delivery system includes a plastic applicator with a flexible, molded tip available in two lengths. The Diastat® AcuDial™ 10-mg syringe is available with a 4.4 cm tip and the Diastat® AcuDial™ 20 mg syringe is available with a 6.0 cm tip. Diastat® 2.5 mg is also available with a 4.4cm tip. In elderly and debilitated patients, it is recommended that the dosage be adjusted downward to reduce the likelihood of ataxia or oversedation. The prescribed dose of Diazepam rectal gel should be adjusted by the physician periodically to reflect changes in the patient¹s age or weight. The Diastat® 2.5 mg dose may also be used as a partial replacement dose for patients who may expel a portion of the first dose.