Desvenlafaxine is an antidepressant in a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). Desvenlafaxine affects chemicals in the brain that may be unbalanced in people with depression.

Desvenlafaxine is used to treat major depressive disorder.

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  • Khedezla, Pristiq
  • Less common
    Chills
    cold sweats
    confusion
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    fast, pounding, or irregular pulse
    headache
    numbness or tingling in the arms or legs
    shakiness in the legs, arms, hands, or feet
    trembling or shaking of the hands or feet
    trouble thinking, speaking, or walking
    weakness
    Incidence not known
    Blistering, peeling, or loose skin
    blood in the stool or urine
    chest tightness
    convulsions (seizures)
    cough
    diarrhea
    dilated or enlarged pupils (black part of the eye)
    feeling irritated
    fever
    hives, itching, rash
    hoarseness
    joint pain, stiffness, or swelling
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    loss of bladder control
    muscle pain
    muscle spasm or jerking of all extremities
    nosebleeds
    red skin lesions, often with a purple center
    red, irritated eyes
    red skin
    sore throat
    sores, ulcers, or white spots in the mouth or on the lips
    sudden loss of consciousness
    swelling of the eyelids, face, lips, hands, or feet
    talking, feeling, or acting with excitement
    trouble breathing or swallowing
    unusual bruising
    unusual tiredness or weakness
    vomiting blood
    Severity: Minor
    Some of the side effects that can occur with desvenlafaxine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Bigger, dilated, or enlarged pupils (black part of the eye)
    decreased appetite
    inability to have an orgasm
    inability to have or keep an erection
    increased sensitivity of the eyes to light
    loss of sexual ability, desire, drive, or performance
    sleepiness or unusual drowsiness
    sleeplessness
    Less common
    Change in taste
    continuous ringing, buzzing, or other unexplained noise in the ears
    decreased weight
    difficult urination
    fear or nervousness
    hearing loss
    increased sensitivity of the eyes to light
    jitteriness
    lack or loss of strength
    loss of taste
  • (oral tablet, extended release)