Divalproex sodium affects chemicals in the body that may be involved in causing seizures.

Divalproex sodium is used to treat various types of seizure disorders. Divalproex sodium is sometimes used together with other seizure medications.

Divalproex sodium is also used to treat manic episodes related to bipolar disorder (manic depression), and to prevent migraine headaches.

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  • Depakote, Depakote ER, Depakote Sprinkles
  • More common
    Black, tarry stools
    bleeding gums
    bloating or swelling of the face, arms, hands, lower legs, or feet
    blood in the urine or stools
    cough or hoarseness
    difficult or labored breathing
    fever or chills
    general feeling of discomfort or illness
    joint pain
    loss of appetite
    lower back or side pain
    mental depression
    muscle aches and pains
    painful or difficult urination
    pinpoint red spots on the skin
    quick to react or overreact emotionally
    rapid weight gain
    rapidly changing moods
    runny nose
    shakiness in the legs, arms, hands, or feet
    sleepiness or unusual drowsiness
    sore throat
    tightness in the chest
    tingling of the hands or feet
    trembling or shaking of the hands or feet
    trouble sleeping
    unusual bleeding or bruising
    unusual tiredness or weakness
    unusual weight gain or loss
    Less common
    Abnormal dreams
    absence of or decrease in body movement
    bloody nose
    blurred vision
    bruising burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    change in personality
    change in walking and balance
    changes in patterns and rhythms of speech
    chest pain
    cloudy urine
    clumsiness or unsteadiness
    cold sweats
    darkened urine
    degenerative disease of the joint
    difficulty with moving
    dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
    dry mouth
    excessive muscle tone
    fast, irregular, pounding, or racing heartbeat or pulse
    feeling of warmth or heat
    flushing or redness of the skin, especially on the face and neck
    frequent urge to urinate
    heavy non-menstrual vaginal bleeding
    increased need to urinate
    lack of coordination
    large, flat, blue or purplish patches in the skin
    leg cramps
    lip smacking or puckering
    loss of bladder control
    loss of strength or energy
    multiple swollen and inflamed skin lesions
    muscle pain or stiffness
    muscle tension or tightness
    normal menstrual bleeding occurring earlier, possibly lasting longer than expected
    pains in the stomach, side, or abdomen, possibly radiating to the back
    passing urine more often
    pounding in the ears
    puffing of the cheeks
    rapid or worm-like movements of the tongue
    rapid weight gain
    seeing, hearing, or feeling things that are not there
    shakiness and unsteady walk
    slurred speech
    small red or purple spots on the skin
    swollen joints
    trouble with speaking
    uncontrolled chewing movements
    uncontrolled movements of the arms and legs
    unsteadiness, trembling, or other problems with muscle control or coordination
    vomiting of blood or material that looks like coffee grounds
    yellow eyes or skin
    If any of the following symptoms of overdose occur while taking divalproex sodium, get emergency help immediately:

    Symptoms of overdose
    Change in consciousness
    loss of consciousness
    slow or irregular heartbeat
    Some of the side effects that can occur with divalproex sodium may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Acid or sour stomach
    body aches or pain
    change in vision
    continuing ringing or buzzing or other unexplained noise in the ears
    hair loss or thinning of the hair
    hearing loss
    impaired vision
    lack or loss of strength
    loss of memory
    problems with memory
    seeing double
    tender, swollen glands in the neck
    trouble with swallowing
    uncontrolled eye movements
    voice changes
    weight gain
    weight loss
    Less common
    Absent, missed, or irregular menstrual periods
    back pain
    burning, dry, or itching eyes
    change in taste or bad unusual or unpleasant (after) taste
    coin-shaped lesions on the skin
    cough producing mucus
    discharge or excessive tearing
    dry skin
    excess air or gas in the stomach or intestines
    eye pain
    feeling of constant movement of self or surroundings
    full feeling
    heavy bleeding
    increased appetite
    itching of the vagina or genital area
    itching skin
    loss of bowel control
    neck pain
    oily skin
    pain during sexual intercourse
    pain or tenderness around the eyes and cheekbones
    passing gas
    rash with flat lesions or small raised lesions on the skin
    redness or swelling in the ear
    redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
    redness, swelling, or soreness of the tongue
    sensation of spinning
    stiff neck
    stopping of menstrual bleeding
    thick, white vaginal discharge with no odor or with a mild odor
  • (divalproex sodium) tablet, extended release