Denosumab is a monoclonal antibody. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.

The Xgeva brand of denosumab is used to prevent bone fractures and other skeletal conditions in people with tumors that have spread to the bone. Xgeva is not for use in people with multiple myeloma (bone marrow cancer).

Xgeva is also used to treat giant cell bone tumor in adults and teenagers with fully matured bone structure.

Xgeva is also used to treat high blood levels of calcium caused by cancer, when other medicines such as pamidronate or zoledronic acid (Zometa) have been used without success.

This medication guide provides information about the Xgeva brand of denosumab. Prolia is another brand of denosumab used to treat osteoporosis in postmenopausal women who have high risk of bone fracture.

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  • Xgeva
  • More common
    Back pain
    blistering, crusting, irritation, itching, or reddening of the skin
    bloody or cloudy urine
    cracked, dry, or scaly skin
    difficult, burning, or painful urination
    frequent urge to urinate
    muscle or bone pain
    pain in the arms or legs
    rash
    skin rash, encrusted, scaly, and oozing
    swelling
    Less common
    Abdominal or stomach cramps
    arm or jaw pain
    bloating or swelling of the face, arms, hands, lower legs, or feet
    body aches or pain
    chest pain or discomfort
    chest tightness or heaviness
    confusion
    congestion
    convulsions
    cough
    difficulty with breathing
    difficulty with moving
    dryness or soreness of the throat
    ear congestion
    fast or irregular heartbeat
    fever or chills
    headache
    hoarseness
    joint pain
    loss of voice
    muscle cramps in the hands, arms, feet, legs, or face
    muscle stiffness
    numbness and tingling around the mouth, fingertips, hands, or feet
    pain in the lower back, bottom, or hips
    pain in the upper leg
    painful blisters on the trunk of the body
    pale skin
    rapid weight gain
    runny or stuffy nose
    sneezing
    swollen joints
    tender, swollen glands in the neck
    tremor
    trouble swallowing
    troubled breathing with exertion
    unusual bleeding or bruising
    unusual tiredness or weakness
    unusual weight gain or loss
    voice changes
    Rare
    Abdominal or stomach discomfort
    blood in the stool
    change in bowel habits
    clear or bloody discharge from the nipple
    constipation
    darkened urine
    difficulty with swallowing or eating
    dimpling of the breast skin
    indigestion
    inverted nipple
    itching, pain, redness, swelling, tenderness, or warmth on the skin
    loss of appetite
    lower back or side pain
    lump in the breast or under the arm
    lump or swelling in the abdomen or stomach
    nausea
    pains in the stomach, side, or abdomen, possibly radiating to the back
    persistent crusting or scaling of the nipple
    raised, firm, and bright red patches of the skin on the arm or leg
    redness or swelling of the breast
    sore on the skin of the breast that does not heal
    unexplained weight loss
    vomiting
    yellow eyes or skin
    Incidence not known
    Heavy feeling in the jaw
    loose teeth
    pain, swelling, or numbness in the mouth or jaw
    Some of the side effects that can occur with denosumab may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Less common
    Dizziness or lightheadedness
    excess air or gas in the stomach or intestines
    feeling of constant movement of self or surroundings
    full feeling
    heartburn
    lack or loss of strength
    passing gas
    redness, pain, itching, burning, swelling, or a lump under your skin where the shot was given
    sensation of spinning
    trouble sleeping
    upper abdominal or stomach pain
  • (subcutaneous solution)