Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID). Oxaprozin works by reducing hormones that cause inflammation and pain in the body.

Oxaprozin is used to treat pain or inflammation caused by osteoarthritis or rheumatoid arthritis in adults. Oxaprozin is also used to treat rheumatoid arthritis in children who are at least 6 years old.

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  • Daypro
  • More common
    Skin rash
    Less common
    Bloating
    bloody or black, tarry stools
    burning upper abdominal pain
    burning while urinating
    cloudy urine
    constipation
    decrease in urine output or decrease in urine-concentrating ability
    diarrhea
    difficult or painful urination
    frequent urination
    headache
    heartburn
    indigestion
    itching skin
    loss of appetite
    nausea or vomiting
    pale skin
    severe abdominal pain, cramping, or burning
    severe and continuing nausea
    swelling
    troubled breathing with exertion
    unusual bleeding or bruising
    unusual tiredness or weakness
    vomiting of blood or material that looks like coffee grounds
    weight loss
    Rare
    Agitation
    bleeding gums
    blistering, peeling, loosening of skin
    blurred vision
    body aches or pain
    burning feeling in chest or stomach
    changes in blood pressure
    chest pain
    clay-colored stools
    coma
    confusion
    cough or hoarseness
    cracks in the skin
    dark urine
    depression
    difficult or labored breathing
    difficulty swallowing
    dilated neck veins
    dizziness
    ear congestion
    extreme fatigue
    fainting
    feeling of discomfort
    fever or chills
    fluid-filled skin blisters
    high fever
    hives or welts
    hostility
    increased sensitivity of skin to sunlight
    increased thirst
    increased volume of pale, dilute urine
    inflammation of joints
    irregular, fast or slow, or shallow breathing
    irritability
    joint or muscle pain
    large, flat, blue or purplish patches in the skin
    large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    lethargy
    light-colored stools
    lightheadedness
    loss of heat from the body
    loss of voice
    lower back or side pain
    muscle aches
    muscle twitching
    nasal congestion
    nervousness
    noisy breathing
    pain or burning in throat
    pain or tenderness around eyes and cheekbones
    pale or blue lips, fingernails, or skin
    pinpoint red or purple spots on skin
    pounding in the ears
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    rapid weight gain
    red skin lesions, often with a purple center
    red, irritated eyes
    redness or other discoloration of skin
    redness, swelling, or soreness of tongue
    scaly skin
    seizures
    severe sunburn
    shortness of breath
    skin thinness
    slow, fast, irregular, pounding, or racing heartbeat or pulse
    sneezing
    sore throat
    sores, ulcers, or white spots on lips or tongue or inside the mouth
    stomach upset
    stuffy or runny nose
    stupor
    swelling of face, fingers, feet, or lower legs
    swelling or inflammation of the mouth
    swollen lymph glands
    tenderness in stomach area
    tightness in chest
    unpleasant breath odor
    upper right abdominal pain
    wheezing
    yellow eyes or skin
    Some of the side effects that can occur with oxaprozin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Acid or sour stomach
    belching
    stomach discomfort
    Less common
    Continuing ringing or buzzing or other unexplained noise in ears
    excess air or gas in stomach or intestines
    hearing loss
    passing gas
    relaxed and calm
    sleepiness or unusual drowsiness
    trouble sleeping
    Rare
    Anxiety
    burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    burning, dry, or itching eyes
    change in taste
    decreased hearing
    discharge, excessive tearing
    dry mouth
    feeling of constant movement of self or surroundings
    general feeling of discomfort or illness
    lack or loss of strength
    redness, pain, swelling of eye, eyelid, or inner lining of eyelid
    sensation of spinning
    shakiness in legs, arms, hands, feet
    sleeplessness
    trembling or shaking of hands or feet
    unable to sleep
  • (oxaprozin) caplets