Preventing or treating acute migraine headache with or without aura (flashing lights, wavy lines, dark spots) and cluster headaches.

D.H.E. 45 is an ergot derivative. It works by constricting blood vessels in the brain, which helps to relieve migraine headaches.

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  • D.H.E. 45
  • All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

    Abnormal skin sensations; anxiety; diarrhea; dizziness; flushing; headache; increased sweating; nausea; vomiting.

    Seek medical attention right away if any of these SEVERE side effects occur:
    Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; difficulty breathing; itching; muscle pain or weakness in the arms and legs; numbness, coldness, loss of color, or tingling in the fingers and toes; swelling; swelling or itching at the injection site; temporary speeding or slowing of the heart rate.
  • D.H.E. 45® (dihydroergotamine mesylate) Injection, USP should be administered in a dose of 1 mL intravenously, intramuscularly or subcutaneously. The dose can be repeated, as needed, at 1 hour intervals to a total dose of 3 mL for intramuscular or subcutaneous delivery or 2 mL for intravenous delivery in a 24 hour period. The total weekly dosage should not exceed 6 mL. D.H.E. 45® (dihydroergotamine mesylate) Injection, USP, should not be used for chronic daily administration.