Progesterone is a female hormone important for ovulation and menstruation. Progesterone causes changes in the lining of your uterus, making it easier for a fertilized egg to attach to the uterus at the beginning of pregnancy. Progesterone then helps your body maintain the pregnancy.

Progesterone vaginal (for use in the vagina) is used to cause menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body.

Progesterone vaginal is also used in fertility treatment as part of Assisted Reproductive Technology (ART) for women unable to get pregnant due to a lack of natural progesterone in the body.

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  • Crinone, Endometrin, FIRST-Progesterone VGS 200, Prochieve
  • Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

    Call your doctor at once if you have:

    unusual vaginal bleeding;
    pain or burning when you urinate;
    symptoms of depression (sleep problems, weakness, mood changes);
    a breast lump;
    sudden vision problems, severe headache or pain behind your eyes;
    heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
    liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
    signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with speech or balance;
    signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or
    signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs.
    Common side effects may include:

    dizziness, confusion, drowsiness, tiredness;
    headache, mood changes, feeling nervous or irritable;
    stomach pain, nausea, diarrhea, constipation;
    bloating, swelling in your hands or feet;
    breast pain, swelling, or tenderness;
    cramps, pelvic pain; or
    vaginal itching, burning, or discharge.
  • Crinone 8% is administered vaginally at a dose of 90 mg once daily in women who require progesterone supplementation. Crinone 8% is administered vaginally at a dose of 90 mg twice daily in women with partial or complete ovarian failure who require progesterone replacement. If pregnancy occurs, treatment may be continued until placental autonomy is achieved, up to 10 to 12 weeks. Secondary Amenorrhea Crinone 4% is administered vaginally every other day up to a total of six doses. For women who fail to respond, a trial of Crinone 8% every other day up to a total of six doses may be instituted. It is important to note that a dosage increase from the 4% gel can only be accomplished by using the 8% gel. Increasing the volume of gel administered does not increase the amount of progesterone absorbed.