Dactinomycin is a cancer medication that interferes with the growth and spread of cancer cells in the body.
Dactinomycin is used to treat different types of cancers that affect the kidneys, uterus, testicles, bones, muscles, joints, and soft tissues. Dactinomycin is also used to treat solid tumors.
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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
pain, swelling, burning, irritation, or skin changes where the injection was given;
fever, chills, body aches, diarrhea, flu symptoms, sores in your mouth and throat;
swelling or tenderness in your upper stomach, weight gain, dark urine, jaundice (yellowing of the skin or eyes);
feeling short of breath, urinating less than usual or not at all;
chest pain, dry cough, wheezing;
pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
any wound that will not heal; or
redness or your skin or the inside of your mouth and throat (if you are also receiving radiation treatment).
Common side effects may include:
nausea, vomiting, stomach pain, loss of appetite;
tired feeling, muscle pain;
rectal pain or bleeding;
numbness or tingly feeling around your mouth, fast or slow heart rate, muscle tightness or contraction, overactive reflexes;
dry or cracked skin, chapped lips; or
acne, mild skin rash.
The dosage for COSMEGEN is calculated in micrograms (mcg). The dose intensity per 2-week cycle for adults or children should not exceed 15 mcg/kg/day or 400-600 mcg/m2/day intravenously for five days. Calculation of the dosage for obese or edematous patients should be performed on the basis of surface area in an effort to more closely relate dosage to lean body mass.