Contrave is combination of naltrexone, an opioid antagonist, and bupropion, an inhibitor of the neuronal reuptake of dopamine and norepinephrine.
Contrave is specifically indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of: 30 kg/m2 or greater (obese) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbidity.
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Adverse effects associated with the use of Contrave may include, but are not limited to, the following:
Dosing should be escalated according to the following schedule: Week 1: Morning dose: 1 tablet Evening dose: no tablet Week 2: Morning dose: 1 tablet Evening dose: 1 tablet Week 3: Morning dose: 2 tablets Evening dose: 1 tablet Week 4 - Onward: Morning dose: 2 tablets Evening dose: 2 tablets