Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Vaginal conjugated estrogens are a mixture of estrogen hormones used to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse.

Vaginal conjugated estrogens should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

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  • Premarin Vaginal, Synthetic Conjugated Estrogens, A
  • More common
    Breast pain
    change in vaginal discharge
    cough or hoarseness
    fever or chills
    increased clear or white vaginal discharge
    itching of the vagina or genital area
    lower back or side pain
    pain during sexual intercourse
    pain or feeling of pressure in the pelvis
    painful or difficult urination
    thick, white vaginal discharge with no odor or with a mild odor
    vaginal bleeding
    Less common
    Feeling faint, dizzy, or lightheaded
    feeling of warmth or heat
    flushing or redness of the skin, especially on the face and neck
    headache
    sweating
    Incidence not known
    Abdominal or stomach bloating
    abnormal uterine bleeding or spotting
    acne
    anxiety
    bloody or cloudy urine
    breast tenderness, enlargement, pain, or discharge
    chest pain or discomfort
    decreased vision or other changes in vision
    difficulty with swallowing
    enlargement of the penis or testes
    fast heartbeat
    frequent urge to urinate
    growth of pubic hair
    hives
    itching
    itching of the vagina or outside genitals
    nausea
    pain during sexual intercourse
    pain or discomfort in the arms, jaw, back, or neck
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    rapid increase in height
    shortness of breath
    stomach pain
    sudden shortness of breath or troubled breathing
    sweating
    tightness in the chest
    unusual tiredness or weakness
    vomiting
    wheezing
    Severity: Minor
    Some of the side effects that can occur with conjugated estrogens topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Abdominal or stomach pain
    back pain
    diarrhea
    headache
    lack or loss of strength
    Less common
    Body aches or pain
    congestion
    increased dryness or soreness of the throat
    runny nose
    tender, swollen glands in the neck
    trouble with swallowing
    voice changes
    Incidence not known
    Abdominal or stomach cramps
    changes in weight
    decreased or increased interest in sexual intercourse
    depression
    difficulty with moving
    headache, severe and throbbing
    heavy bleeding
    inability to have or keep an erection
    increased hair growth, especially on the face
    irritability
    itching of the vagina or genitals
    leg cramps
    loss of scalp hair
    loss or increase in sexual ability, desire, drive, or performance
    mood changes
    muscle pain or stiffness
    nervousness
    pain
    pain in the joints
    patchy brown or dark brown discoloration of the skin
    poor insight and judgment
    problems with memory or speech
    swelling of the breasts or breast soreness in both females and males
    trouble recognizing objects
    trouble thinking and planning
    weakness
  • (vaginal cream with applicator)