Treating menopausal symptoms (eg, hot flashes, vaginal dryness). It is used to prevent osteoporosis (weak bones) after menopause in certain patients. It may also be used for other conditions as determined by your doctor.

Conjugated estrogens/medroxyprogesterone is a combination of estrogen and progestin hormones. It works by replacing these hormones in the body when the body does not make enough on its own.

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  • Premphase and Prempro
  • Less common
    Bloating or swelling of the face, arms, hands, lower legs, or feet
    blood in the urine
    blurred vision
    chest pain
    clear or bloody discharge from the nipple
    cough or hoarseness
    dimpling of the breast skin
    fast, irregular, pounding, or racing heartbeat or pulse
    feeling faint, dizzy, or lightheaded
    feeling of warmth or heat
    fever or chills
    flushing or redness of the skin, especially on the face and neck
    inverted nipple
    lower back or side pain
    lump in the breast or under the arm
    pain during sexual intercourse
    painful or difficult urination
    persistent crusting or scaling of the nipple
    pounding in the ears
    redness or swelling of the breast
    severe cramping of the uterus
    sore on the skin of the breast that does not heal
    thick, white vaginal discharge with no odor or with a mild odor
    tingling of the hands or feet
    unusual weight gain or loss
    vaginal bleeding that is unusual and heavy
    vaginal or genital itching
    vaginal yeast infection
    Incidence not known
    Absent, missed, or irregular menstrual periods
    acid or sour stomach
    breast pain or tenderness
    darkened urine
    decreased vision or other changes in vision
    difficulty with speaking
    double vision
    inability to move the arms, legs, or facial muscles
    inability to speak
    loss of appetite
    pain or discomfort in the arms, jaw, back, or neck
    pain or feeling of pressure in the pelvis
    pain, redness, or swelling in the arm or leg
    painful or tender cysts in the breasts
    pains in the stomach, side, or abdomen, possibly radiating to the back
    slow speech
    sudden shortness of breath or troubled breathing
    unexpected or excess milk flow from the breasts
    yellow eyes or skin
    Severity: Minor
    Some of the side effects that can occur with conjugated estrogens / medroxyprogesterone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Back pain
    excess gas in the stomach or intestines
    lack or loss of strength
    Less common
    Blemishes on the skin
    body aches or pain
    difficulty with moving
    dry skin
    dryness of the vagina
    excessive muscle tone
    feeling paranoid
    flu-like symptoms
    fullness or swelling of the breasts
    hair loss or thinning of the hair
    headache, severe and throbbing
    leg cramps
    loss of bladder control
    menstrual periods that are longer or heavier
    muscle pain or stiffness
    pain in the joints
    pain or tenderness around the eyes and cheekbones
    pimples or acne
    quick to react or overreact emotionally
    rapidly changing moods
    sore mouth or tongue
    stuffy or runny nose
    tender, swollen glands in the neck
    tightness of the chest or wheezing
    trouble with sleeping
    trouble with swallowing
    vaginal discharge that is clear or white
    voice changes
    white patches in the mouth or on the tongue
    Incidence not known
    Changes in appetite
    hives or welts
    inability to have or keep an erection
    increased hair growth, especially on the face
    increased interest in sexual intercourse
    loss in sexual ability, desire, drive, or performance
    loss of scalp hair
    pain in the ankles or knees
    painful, red lumps under the skin, mostly on the legs
    patchy brown or dark brown discoloration of the skin
    redness of the skin
    weight changes
  • (oral tablet)