Cometriq (cabozantinib) interferes with the expansion of some cancer cells.
Cometriq is employed to treat thyroid cancer that has unfold to alternative elements of the body.
Cometriq can also be used for functions unlisted during this medication guide.
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Get emergency medical help if you have any signs of an allergic reaction to Cometriq: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some people taking Cometriq have developed a perforation (a hole or tear) or a fistula (an abnormal passageway) within the stomach or intestines. Call your doctor if you have severe stomach pain, or if you feel like you are choking and gagging when you eat or drink.
Stop using Cometriq and call your doctor at once if you have:
bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
heavy menstrual bleeding, or any other bleeding that will not stop;
sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
change in mental status, seizure (convulsions);
pain, swelling, warmth, or redness in one or both legs;
chest pain spreading to the arm or shoulder, sudden cough, wheezing, sweating, rapid breathing;
a light-headed feeling, like you might pass out;
puffy eyes, swelling in your ankles or feet, weight gain, urine that looks foamy;
dangerously high blood pressure (buzzing in your ears, anxiety, shortness of breath, uneven heartbeats); or
jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work.
Once you have had any of the side effects listed above, you may never be able to use Cometriq again. If you stop taking this medicine for any reason, talk to your doctor before you start taking it again.
Also call your doctor at once if you have any of these other side effects while using Cometriq:
severe or ongoing vomiting or diarrhea;
a wound that will not heal;
pain, tenderness, redness, swelling, blistering, or peeling skin on the palms of your hands or the soles of your feet;
severe mouth pain that interferes with eating or drinking;
fever, flu symptoms, easy bruising;
dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
numbness or tingly feeling around your mouth, muscle tightness or contraction, overactive reflexes.
Common side effects may include:
nausea, diarrhea, constipation;
mild mouth discomfort, changes in your sense of taste;
feeling weak or tired, decrease in appetite or weight; or
hoarseness in your voice, changes in your hair color.
The recommended daily dose of COMETRIQ is 140 mg (one 80-mg and three 20-mg capsules). Do not administer COMETRIQ with food. Instruct patients not to eat for at least 2 hours before and at least 1 hour after taking COMETRIQ. Continue treatment until disease progression or unacceptable toxicity occurs. Swallow COMETRIQ capsules whole. Do not open COMETRIQ capsules. Do not take a missed dose within 12 hours of the next dose.