Colesevelam is a cholesterol-lowering drug.

Colesevelam lowers “bad” cholesterol in the blood, which is also called LDL (low-density lipoprotein) cholesterol. Lowering your LDL cholesterol may reduce your risk of hardened arteries, which can lead to heart attacks, stroke, and circulation problems.

Colesevelam is sometimes used together with another cholesterol-lowering medication such as atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), rosuvastatin (Crestor), or simvastatin (Zocor).

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  • Welchol
  • Less common
    Anxiety
    blurred vision
    chills
    cold sweats
    coma
    confusion
    congestion
    cool, pale skin
    cough
    depression
    diarrhea
    dizziness
    dry or sore throat
    fast heartbeat
    fever
    general feeling of discomfort or illness
    headache
    hoarseness
    increased hunger
    joint pain
    loss of appetite
    muscle aches or pain
    nausea
    nervousness
    nightmares
    pounding in the ears
    runny nose
    seizures
    shakiness
    shivering
    slow or fast heartbeat
    slurred speech
    sweating
    tender, swollen glands in the neck
    trouble with sleeping
    trouble with swallowing
    unusual tiredness or weakness
    voice changes
    vomiting
    Incidence not known
    Bleeding after defecation
    darkened urine
    difficulty with swallowing
    indigestion
    pain or discomfort in the chest
    pains in the stomach, side, or abdomen, possibly radiating to the back
    pressure in the stomach
    severe stomach pain
    swelling of the abdominal or stomach area
    unable to swallow saliva
    uncomfortable swelling around the anus
    yellow eyes or skin
    Severity: Minor
    Some of the side effects that can occur with colesevelam may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Acid or sour stomach
    belching
    bloating
    constipation
    full or bloated feeling
    heartburn
    pain or cramping in the abdomen or stomach
    stomach discomfort, upset, or pain
    Less common
    Lack or loss of strength
    sneezing
    stuffy nose
  • (oral tablet, oral powder for reconstitution)