Clozapine is associate degree tranquilliser medication. It works by dynamic the actions of chemicals within the brain.

Clozapine is employed to treat severe schizophrenic psychosis, or to scale back the danger of dangerousbehavior in individuals with schizophrenic psychosis or similar disorders.

Clozapine is offered solely from a licensed pharmacy underneath a special program. you want to be registeredwithin the program and conform to bear frequent blood tests.

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  • Clozaril, FazaClo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex
  • Get emergency medical help if you have signs of an allergic reaction to clozapine: hives, skin pain, rash that spreads and causes blistering or peeling; difficult breathing; swelling of your face, lips, tongue, or throat.

    Serious and sometimes fatal infections may occur during treatment with clozapine. Call your doctor right away if you have signs of infection such as: sudden weakness or ill feeling; fever, swollen glands, sore throat, flu symptoms; or mouth sores, red or swollen gums, and trouble swallowing.

    High doses or long-term use of clozapine can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. The longer you take this medicine, the more likely you are to develop a serious movement disorder. The risk of this side effect is higher in women and older adults.

    Also call your doctor at once if you have:

    headache with chest pain and severe dizziness, pounding heartbeats or fluttering in your chest;
    a light-headed feeling, like you might pass out;
    sudden cough, rapid breathing, coughing up blood;
    tight feeling in your neck or jaw, twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
    a seizure (black-out or convulsions);
    swelling, rapid weight gain, little or no urinating;
    severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;
    high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss; or
    signs of inflammation in your body - easy bruising or bleeding, severe tingling or numbness, muscle weakness, upper stomach pain, jaundice (yellowing of the skin or eyes), chest pain, new or worsening cough, trouble breathing.
    Common clozapine side effects may include:

    weight gain;
    tremor, dizziness, spinning sensation;
    headache, drowsiness;
    fast heart rate;
    nausea, constipation;
    dry mouth, or increased salivation;
    blurred vision; or
    increased sweating.
  • Initial dose: 12.5 mg orally once or twice a day Titration and Maintenance: May increase total daily dose in increments of 25 mg to 50 mg per day to a target dose of 300 mg to 450 mg per day (administered in divided doses) by the end of week 2. Subsequent dose increases can be in increments of up to 100 mg once or twice weekly. Maximum dose: 900 mg per day Comments: -The absolute neutrophil count (ANC) must be 2000/mm3 or greater and WBC count 3500 mm3 or greater, prior to initiating treatment; the ANC and WBC must be monitored regularly during therapy. -A low starting dose, gradual titration, and divided doses are necessary to minimize the risk of orthostatic hypotension, bradycardia, and syncope. -When therapy is interrupted for 2 or more days, re-initiate with 12.5 mg once or twice a day; based on tolerability, a dose that is restarted may be increased to a previously therapeutic dose more quickly than it was for initial treatment.