Treating high blood pressure. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.

Clonidine extended-release tablets are an alpha agonist. It works by relaxing blood vessels and decreasing heart rate, which lowers blood pressure.

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  • Nexiclon XR
  • Less common
    Mental depression
    swelling of the feet and lower legs
    Rare
    Anxiety
    blistering, burning, crusting, dryness, or flaking of the skin
    chest pain or discomfort
    confusion as to time, place, or person
    decreased urine output
    dilated neck veins
    drowsiness
    dry mouth
    fast, pounding, or irregular heartbeat or pulse
    fever
    general feeling of discomfort or illness
    holding false beliefs that cannot be changed by fact
    hyperventilation
    irregular breathing
    irritability
    itching, scaling, severe redness, soreness, or swelling of the skin
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    lightheadedness, dizziness, or fainting
    mental depression
    paleness or cold feeling in the fingertips and toes
    pounding, slow heartbeat
    problems in urination or increase in the amount of urine
    raised red swellings on the skin, lips, tongue, or in the throat
    restlessness
    seeing or hearing things that are not there
    shaking
    shortness of breath
    skin rash
    swelling of the face, fingers, feet, or lower legs
    tightness in the chest
    tingling or pain in the fingers or toes when exposed to cold
    trouble with sleeping
    troubled breathing
    unusual excitement, nervousness, or restlessness
    unusual tiredness or weakness
    vivid dreams or nightmares
    weight gain
    wheezing
    If any of the following symptoms of overdose occur while taking clonidine, get emergency help immediately:

    Symptoms of overdose
    Dizziness (extreme) or faintness
    feeling cold
    pinpoint pupils of the eyes
    unusual tiredness or weakness (extreme)
    Severity: Minor
    Some of the side effects that can occur with clonidine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Constipation
    Less common
    Darkening of the skin
    decreased sexual ability
    dry, itching, or burning eyes
    loss of appetite
    nausea or vomiting
    Rare
    Blurred vision
    decreased interest in sexual intercourse
    hair loss or thinning of the hair
    inability to have or keep an erection
    leg cramps
    loss in sexual ability, desire, drive, or performance
    muscle or joint pain
    pale skin
    swelling of the breasts or breast soreness in both females and males
    weakness
  • (oral tablet, transdermal film, extended release, injectable solution, oral tablet, extended release, oral suspension, extended release, compounding powder)