Treating high blood pressure. It may also be used for other conditions as determined by your doctor.

Chlorthalidone/clonidine is a combination alpha agonist and diuretic. The alpha agonist works by relaxing blood vessels and decreasing heart rate. The diuretic works by increasing elimination of sodium and water.

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  • Clorpres
  • Signs and symptoms of overdose
    Difficulty in breathing
    dizziness (extreme) or faintness
    feeling cold
    pinpoint pupils of eyes
    slow heartbeat
    unusual tiredness or weakness (extreme)
    Severity: Moderate
    If any of the following side effects occur while taking chlorthalidone / clonidine, check with your doctor or nurse as soon as possible:

    Signs and symptoms of too much potassium loss
    Dryness of mouth
    increased thirst
    irregular heartbeat
    mood or mental changes
    muscle cramps or pain
    nausea or vomiting
    weak pulse
    Signs and symptoms of too much sodium loss
    Confusion
    convulsions (seizures)
    decreased mental activity
    irritability
    muscle cramps
    unusual tiredness or weakness
    Less common
    Mental depression
    swelling of feet and lower legs
    Rare
    Black, tarry stools
    blood in urine or stools
    cough or hoarseness
    fever or chills
    joint pain
    lower back or side pain
    paleness or cold feeling in fingertips and toes
    pinpoint red spots on skin
    skin rash or hives
    stomach pain (severe) with nausea and vomiting
    unusual bleeding or bruising
    vivid dreams or nightmares
    yellow eyes or skin
    Severity: Minor
    Some of the side effects that can occur with chlorthalidone / clonidine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Constipation
    dizziness
    drowsiness
    dryness of mouth
    unusual tiredness or weakness
    Less common
    Decreased sexual ability
    diarrhea
    dizziness or lightheadedness when getting up from a lying or sitting position
    dry, itching, or burning eyes
    increased sensitivity of skin to sunlight
    loss of appetite
    nausea or vomiting
    nervousness
    upset stomach
    Side Effects: Post Treatment
    After you stop taking this drug, it is possible that you may still experience side effects that need medical attention. If you notice any of the following side effects check with your doctor immediately:

    Anxiety or tenseness
    chest pain
    fast or pounding heartbeat
    headache
    increased salivation
    nausea
    nervousness
    restlessness
    shaking or trembling of hands and fingers
    stomach cramps
    sweating
    trouble in sleeping
    vomiting
  • (oral tablet)