Cerdelga (eliglustat) reduces the formation of a precise supermolecule within the body in individuals with kind oneGaucher unwellness.
Gaucher unwellness could be a genetic condition within which the body lacks the protein required to interruptdown sure fatty materials (lipids). Lipids will build up within the body, inflicting symptoms like straightforwardbruising or injury, weakness, anemia, bone or joint pain, enlarged liver or spleen, or weakened bones that ar simplybroken.
Cerdelga is employed to treat gentle to moderate kind one Gaucher unwellness in adults. Eliglustat is employed on condition that a selected liver protein (2D6) in your body breaks down or metabolizes medication at a precise rate.
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Get emergency medical help if you have any of these signs of an allergic reaction to Cerdelga: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
headache with chest pain;
a light-headed feeling, like you might pass out; or
pounding heartbeats or fluttering in your chest.
Common Cerdelga side effects may include:
diarrhea, nausea, stomach pain;
back pain; or
pain in your arms or legs.
Usual Adult Dose for Gaucher Disease: CYP450 2D6 Extensive metabolizers (EMs) and Intermediate Metabolizers (IMs): 84 mg orally twice a day CYP450 2D6 Poor Metabolizers (PMs): 84 mg orally once a day EMs and IMs taking strong or moderate CYP450 2D6 inhibitors: 84 mg orally once a day EMs taking strong or moderate CYP450 3A inhibitors: 84 mg orally once a day Comments: It is recommended to establish the CYP450 2D6 genotype of each patient using an FDA-cleared test before starting treatment. Use: Long-term treatment of patients with Gaucher disease type 1 who are CYP450 2D6 extensive metabolizers, intermediate metabolizers, or poor metabolizers.