Carbaglu (carglumic acid) could be a synthetic type of AN catalyst that happens naturally within the liver. Thiscatalyst is important for process excess N created once the body metabolizes proteins. while not this catalyst, Nbuilds up within the type of ammonia and isn’t off from the body. Ammonia is extremely toxicant once it circulates in blood and tissues and might cause permanent brain harm, coma, or death.
Carbaglu is employed to treat hyperammonemia (HYE-per-AM-moe-NEE-mee-a), a organic compound cycle disorder caused by lack of a particular liver catalyst. Carbaglu is sometimes given with alternative medications to treat thiswomb-to-tomb disorder.
Carbaglu may additionally be used for functions ex-directory during this medication guide.
Submit your review
Get emergency medical help if you have any of these signs of an allergic reaction to Carbaglu: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
fever, chills, body aches, flu symptoms, sores in your mouth and throat;
pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
pain or fullness in your ear, hearing problems.
Less serious Carbaglu side effects may include:
vomiting, diarrhea, stomach pain;
stuffy nose, sore throat.
The recommended initial dose for acute hyperammonemia is 100 mg/kg/day to 250 mg/kg/day. Concomitant administration of other ammonia lowering therapies is recommended. Dosing should be titrated based on individual patient plasma ammonia levels and clinical symptoms. The recommended maintenance dose should be titrated to target normal plasma ammonia level for age. Based on limited data in 22 patients receiving maintenance treatment with Carbaglu® in a retrospective case series, maintenance doses were usually less than 100 mg/kg/day. The total daily dose should be divided into 2 to 4 doses and rounded to the nearest 100 mg (i.e., half of a Carbaglu® Tablet).