Busulfan is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Busulfan taken by mouth is used to treat the symptoms of chronic myelogenous leukemia (a type of blood cancer). Busulfan injection is used together with a medicine called cyclophosphamide, to prepare your body to receive a stem cell transplant from a donor’s bone marrow.

Busulfan is not a cure for leukemia.

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  • Busulfex, Myleran
  • More common
    Black, tarry stools
    bloated abdomen or stomach
    blood in the urine or stools
    blurred vision
    chest pain
    cough or hoarseness
    dizziness
    fast or irregular breathing
    fast, pounding, or irregular heartbeat or pulse
    fever or chills
    headache
    lower back or side pain
    nervousness
    pain and fullness in the upper abdominal or stomach
    painful or difficult urination
    pinpoint red spots on the skin
    pounding in the ears
    skin rash or itching
    slow heartbeat
    swelling of the eyes or eyelids
    tightness in the chest
    trouble breathing
    unusual bleeding or bruising
    weight gain
    yellow eyes and skin
    Incidence not known
    seizures
    Severity: Minor
    Some of the side effects that can occur with busulfan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Acid or sour stomach
    back pain
    belching
    bloody nose
    depression
    diarrhea
    difficulty having a bowel movement (stool)
    fear
    heartburn
    indigestion
    loss of appetite
    lack or loss of strength
    sneezing
    stomach discomfort or upset
    stuffy nose or runny nose
    swelling or inflammation of the mouth
    tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over affected area
    trouble sleeping
  • (oral tablet, intravenous solution)