Bridion (sugammadex) is a modified gamma cyclodextrin.
Bridion is specifically indicated for the reversal of neuromuscular blockade induced by rocuronium and vecuronium in adults undergoing surgery.
Bridion is supplied as an injection for intravenous administration. Monitor for twitch responses to determine the timing and dose for Bridion administration.
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Adverse effects associated with the use of Bridion may include, but are not limited to, the following:
The recommended dose is as follows: For rocuronium and vecuronium: 4 mg/kg is recommended if spontaneous recovery of the twitch response has reached 1 to 2 post-tetanic counts (PTC) and there are no twitch responses to train-of-four (TOF) stimulation. 2 mg/kg is recommended if spontaneous recovery has reached the reappearance of the second twitch in response to TOF stimulation. For rocuronium only: 16 mg/kg is recommended if there is a clinical need to reverse neuromuscular blockade soon (approximately 3 minutes) after administration of a single dose of 1.2 mg/kg of rocuronium.