Bosentan lowers blood pressure in your lungs, helping your heart pump blood more efficiently.

Bosentan is used to treat pulmonary arterial hypertension (PAH). It improves your ability to exercise and prevents your condition from getting worse.

Bosentan is available only under a special program from a certified pharmacy. You must be registered in the program and understand the risks and benefits of taking this medication.

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  • Tracleer
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking bosentan:

    More common:
    Blurred vision
    confusion
    dizziness
    dark urine
    faintness or lightheadedness when getting up from a lying or sitting position
    fever with or without chills
    light-colored stools
    loss of appetite
    nausea and vomiting
    stomach pain
    sudden sweating
    unusual tiredness or weakness
    yellow eyes or skin
    Less common:
    Swelling
    Incidence not known:
    Black, tarry stools
    bleeding gums
    blood in the urine or stools
    blue lips and fingernails
    chest pain
    chills
    clay-colored stools
    coughing that sometimes produces a pink frothy sputum
    coughing up blood
    dark urine
    decrease in the amount of urine
    difficult, fast, or noisy breathing, sometimes with wheezing
    fainting
    fast heartbeat
    fatigue on exertion
    fever
    headache
    hives
    hoarseness
    increased sweating
    irritation
    itching
    joint pain, stiffness, or swelling
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    noisy, rattling breathing
    pale skin
    pinpoint red spots on the skin
    rash
    redness of the skin
    shortness of breath
    swelling of the eyelids, face, lips, hands, fingers, legs, ankles, or feet
    tightness in the chest
    troubled breathing at rest
    troubled breathing or swallowing
    troubled breathing with exertion
    unpleasant breath odor
    unusual bleeding or bruising
    vomiting of blood
    weight gain
    wheezing
    If any of the following symptoms of overdose occur while taking bosentan, get emergency help immediately:

    Symptoms of overdose:
    Increased heart rate
    Severity: Minor
    Some of the side effects that can occur with bosentan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common:
    Fast, irregular, pounding, or racing heartbeat or pulse
    feeling of warmth
    muscle aches
    redness of the face, neck, arms, and occasionally upper chest
    sore throat
    stuffy or runny nose
    Less common:
    Acid or sour stomach
    belching
    heartburn
    indigestion
    stomach discomfort, upset, or pain
  • (oral tablet)