Belimumab is a monoclonal antibody that affects the actions of the body’s immune system. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage.

Belimumab is used to treat active systemic lupus erythematosus (SLE) in adults.

Belimumab is not for use in people who have severe kidney problems caused by SLE, or have active SLE that affects the central nervous system (brain, nerves, and spinal cord).

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  • Benlysta
  • More common
    Bleeding, blistering, burning, coldness, skin discoloration, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
    body aches or pain
    chest congestion
    chills
    cough
    diarrhea
    difficulty with breathing or swallowing
    dizziness
    ear congestion
    fever
    headache
    hives
    itching, pain, redness, swelling, tenderness, or warmth of the skin
    joint pain
    loss of appetite
    lower back or side pain
    muscle aches and pains
    nausea or vomiting
    pain or tenderness around the eyes and cheekbones
    swelling of the eyes, face, or inside of the nose
    shortness of breath or trouble breathing
    sneezing
    sore throat
    stuffy or runny nose
    sweating
    tightness in the chest
    unusual tiredness or weakness
    Less common
    Black, tarry stools
    bloody or cloudy urine
    depression
    difficult, burning, or painful urination
    fast heartbeat
    frequent urge to urinate
    hoarseness
    sores, ulcers, or white spots on the lips or in the mouth
    swollen glands
    tender, swollen glands in the neck
    unusual bleeding or bruising
    voice changes
    Severity: Minor
    Some of the side effects that can occur with belimumab may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common
    Arm or leg pain
    headache, severe and throbbing
    unable to sleep
    Less common
    Abdominal or stomach pain
    weakness
  • (intravenous powder for injection)