Baclofen may be a muscle agent associated an antispastic agent.
Baclofen is employed to treat muscle symptoms caused by sclerosis, as well as spasm, pain, and stiffness.

Baclofen might also be used for functions unlisted during this medication guide.

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  • Lioresal, Lioresal Intrathecal, Gablofen
  • Get emergency medical help if you have any of these signs of an allergic reaction to baclofen: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

    Call your doctor at once if you have a serious side effect such as:

    seizure (convulsions);
    confusion, hallucinations; or
    an uneven heartbeat.
    Less serious baclofen side effects may include:

    drowsiness, dizziness, weakness, tired feeling;
    sleep problems (insomnia);
    nausea, constipation; or
    urinating more often than usual.
  • Oral: Initial dose: 5 mg orally 3 times a day for 3 days, then 10 mg orally 3 times a day for 3 days, then 15 mg orally 3 times a day for 3 days, then 20 mg orally 3 times a day. Maintenance dose: 40-80 mg/day. 80 mg/day doses should be administered in 4 divided doses. Intrathecal: Test dose: 50 mcg (in a volume of 1 mL) injected into the intrathecal space by barbotage over at least 1 minute. Observe patient for 4-8 hours for a positive response. Second test dose: If no positive response to first test dose, 75 mcg (in a volume of 1.5 mL) may be administered 24 hours later. Third test dose: If no positive response to second test dose, 100 mcg (in a volume of 2 mL) may be administered 24 hours later. If no positive response to third test dose, the patient should not be considered for chronic intrathecal therapy. The test dose that received a positive response should be doubled and given over 24 hours. If the test dose maintained a positive response for > 12 hours, the starting daily dose should be the same as the effective test dose. After 24 hours, the dose may be titrated by 10%-20% increments every day until the desired clinical effect is achieved. Over time, many patients will require gradual dose increases to maintain the desired clinical effect. Patients have been maintained on daily doses of 12-1500 mcg. Most patients require 300-800 mcg/day.