Atropine blocks the action of chemical called acetylcholine (ah see til KO leen), which may exist in high levels in the body after a poisoning. Atropine also stimulates the heart and reduces the secretions of the nose, mouth, and lungs to improve breathing.

Pralidoxime reverses muscle weakness or paralysis caused by a poison or nerve agent.

The combination of atropine and pralidoxime is used as an antidote to treat poisoning by a pesticide (insect spray) or a chemical that interferes with the central nervous system, such as nerve gas.

This medication is not effective as an antidote for all types of pesticide poisonings. You may need medications or additional treatments.

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  • DuoDote
  • pounding heartbeats or fluttering in your chest;
    painful or difficult urination;
    trouble swallowing;
    feeling like you might pass out;
    confusion;
    loss of movement in any part of your body;
    slow heart rate, weak pulse, fainting, slow breathing (breathing may stop); or
    chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.
    Less serious side effects of atropine / pralidoxime may include:

    dry mouth, dry nose, dry skin;
    dry eyes, blurred vision;
    increased sensitivity of your eyes to light;
    headache;
    dizziness, drowsiness;
    muscle weakness;
    constipation, stomach pain, bloating, nausea, vomiting;
    loss of interest in sex, impotence; or
    mild skin rash.
  • (intramuscular solution)