Asenapine is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

Asenapine is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression) in adults.

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  • Saphris, Saphris Black Cherry
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking asenapine:

    More common:
    Abnormal or decreased touch sensation
    inability to move the eyes
    inability to sit still
    increase in body movements
    increased blinking or spasms of the eyelid
    lip smacking or puckering
    need to keep moving
    puffing of the cheeks
    rapid or worm-like movements of the tongue
    restlessness
    shakiness in the legs, arms, hands, or feet
    sticking out of tongue
    trembling or shaking of the hands or feet
    trouble with breathing, speaking, or swallowing
    twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
    uncontrolled chewing movements
    uncontrolled twisting movements of the neck, trunk, arms, or legs
    unusual facial expressions
    weakness of the arms and legs
    Less common:
    Blurred vision
    dizziness
    headache
    nervousness
    pounding in the ears
    slow or fast heartbeat
    Rare:
    Black, tarry stools
    bleeding gums
    blood in the urine or stools
    burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    changes in patterns and rhythms of speech
    coma
    confusion
    convulsions
    decreased urine output
    fast, pounding, or irregular heartbeat or pulse
    increased thirst
    muscle pain or cramps
    nausea or vomiting
    pale skin
    pinpoint red spots on the skin
    slurred speech
    swelling of the face, ankles, or hands
    troubled breathing with exertion
    unusual bleeding or bruising
    unusual tiredness or weakness
    Severity: Minor
    Some of the side effects that can occur with asenapine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common:
    Constipation
    sleepiness or unusual drowsiness
    trouble sleeping
    unusually deep sleep
    unusually long duration of sleep
    Less common:
    Acid or sour stomach
    belching
    depression
    difficulty with moving
    dry mouth
    fear or nervousness
    heartburn
    increased appetite
    increased watering of the mouth
    increased weight
    indigestion
    irritability
    muscle pain or stiffness
    pain in the arms or legs
    pain in the joints
    stomach discomfort, upset, or pain
    toothache
  • (sublingual tablet)