Acetaminophen is a pain reliever and a fever reducer.

Aspirin is in a group of drugs called salicylates (sa-LIS-il-ates). It works by reducing substances in the body that cause pain, fever, and inflammation.

Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.

Acetaminophen, aspirin, and caffeine is a combination medicine used to treat pain caused by tension headaches, migraine headaches, muscle aches, menstrual cramps, arthritis, toothaches, the common cold, or nasal congestion.

Do not use aspirin for heart or blood vessel conditions unless your doctor tells you to.

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  • Anacin Advanced Headache Formula, Arthriten, Backaid IPF, Excedrin, Excedrin Menstrual Express Gels, Excedrin Migraine, Goody's Headache Powders, Pain Reliever Plus, Pamprin Max
  • Heartburn; nausea; upset stomach.

    Seek medical attention right away if any of these SEVERE side effects occur while taking acetaminophen / aspirin / caffeine:
    Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; fainting; hearing loss; ringing in the ears; symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, right-upper stomach pain, yellowing of the skin or eyes); unusual tiredness.
  • (oral tablet, oral powder for reconstitution)