Trihexyphenidyl alters unusual nerve impulses and relaxes stiff muscles.

Trihexyphenidyl is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson’s disease. It is also used to treat and prevent the same muscular conditions when they are caused by drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), haloperidol (Haldol), thiothixene (Navane), and others.

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  • Artane, Trihexane
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking trihexyphenidyl:

    Rare:
    Abdominal or stomach cramps or pain
    bloating
    constipation
    delusions of persecution, mistrust, suspiciousness, or combativeness
    excessive dryness of the mouth
    false beliefs that cannot be changed by facts
    loss of appetite
    nausea or vomiting
    seeing, hearing, or feeling things that are not there
    skin rash
    stomach pain
    swollen, painful, or tender lymph glands on the side of the face or neck
    Incidence not known:
    Anxiety
    blurred vision
    change in vision
    decrease in frequency of urination
    decrease in urine volume
    difficult urination
    difficulty in passing urine (dribbling)
    disturbed behavior
    dry mouth
    enlarged pupils
    eye pain
    fast, pounding, or irregular heartbeat or pulse
    hyperventilation
    irritability
    loss of vision
    mental confusion
    nervousness
    painful urination
    restlessness
    shaking
    shortness of breath
    trouble sleeping
    Severity: Minor
    Some of the side effects that can occur with trihexyphenidyl may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common:
    Dizziness
    mild nausea
    nervousness
    Incidence not known:
    Drowsiness
    weakness
  • (oral tablet, oral elixir)