Methyclothiazide is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Methyclothiazide is used to treat fluid retention (edema) that is caused by congestive heart failure, severe liver disease (cirrhosis), kidney disease, or treatment with a steroid or hormone medicine .

Methyclothiazide is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps to lower blood pressure .

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  • Aquatensen, Enduron
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking methyclothiazide:

    Incidence not known:
    Abdominal or stomach pain
    back, leg, or stomach pains
    black, tarry stools
    bleeding gums
    blistering, peeling, or loosening of skin
    bloating
    blood in urine or stools
    bloody urine
    blue lips and fingernails
    blurred vision
    burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    chest pain
    chills
    clay-colored stools
    cloudy urine
    cold sweats
    confusion
    constipation
    cough or hoarseness
    coughing that sometimes produces a pink frothy sputum
    coughing up blood
    cracks in the skin
    darkened urine
    decrease in urine output or decrease in urine-concentrating ability
    decreased frequency or amount of urine
    diarrhea
    difficult, fast, or noisy breathing, sometimes with wheezing
    difficulty swallowing
    dizziness, faintness, or lightheadedness when getting up from lying or sitting position
    dry mouth
    fast or irregular heartbeat
    fever
    flushed, dry skin
    fruit-like breath odor
    general body swelling
    general feeling of discomfort or illness
    general feeling of tiredness or weakness
    greatly decreased frequency of urination or amount of urine
    headache
    hives
    increased blood pressure
    increased hunger
    increased sweating
    increased thirst
    increased urination
    indigestion
    itching
    joint pain, stiffness, or swelling
    loss of appetite
    loss of heat from the body
    lower back or side pain
    muscle cramps or pain
    nausea or vomiting
    nosebleeds
    numbness, tingling, pain, or weakness in hands or feet
    pain in joints or muscles
    painful or difficult urination
    pains in stomach, side, or abdomen, possibly radiating to the back
    pale skin
    pinpoint red spots on skin
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    rash
    red, irritated eyes
    red skin lesions, often with a purple center
    red, swollen skin
    redness, soreness, or itching skin
    scaly skin
    seizures
    shortness of breath
    sore throat
    sores, ulcers, or white spots on lips or in mouth
    sores, welting or blisters
    sugar in the urine
    swelling of face, fingers, legs, ankles, feet, or lower legs
    swollen or painful glands
    tenderness of salivary glands
    thickening of bronchial secretions
    tightness in chest
    trembling
    troubled breathing
    unpleasant breath odor
    unusual bleeding or bruising
    unusual tiredness or weakness
    unusual weight loss
    vomiting of blood
    weakness and heaviness of legs
    weight gain
    wheezing
    yellow eyes or skin
    Severity: Minor
    Some of the side effects that can occur with methyclothiazide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Incidence not known:
    Cramping
    decreased interest in sexual intercourse
    difficulty having a bowel movement (stool)
    feeling of constant movement of self or surroundings
    hair loss, thinning of hair
    inability to have or keep an erection
    increased sensitivity of skin to sunlight
    loss in sexual ability, desire, drive, or performance
    muscle spasm
    pinpoint red or purple spots on skin
    redness or other discoloration of skin
    restlessness
    sensation of spinning
    severe sunburn
    weakness
  • (oral tablet, compounding powder)