Orphenadrine is used to help relax certain muscles in your body and relieve the stiffness, pain, and discomfort caused by strains, sprains, or other injury to your muscles. However, this medicine does not take the place of rest, exercise or physical therapy, or other treatment that your doctor may recommend for your medical problem .

Orphenadrine acts in the central nervous system (CNS) to produce its muscle relaxant effects .

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  • Antiflex ,Mio-Rel ,Norflex, Orfro ,Orphenate
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking orphenadrine:

    Rare:
    Chest pain
    chills
    cough
    fever
    hallucinations (seeing, hearing, or feeling things that are not there)
    headache
    shortness of breath, troubled breathing, tightness in chest, and/or wheezing
    skin rash, hives, itching, or redness
    sores, ulcers, or white spots on lips or in mouth
    swollen and/or painful glands
    unusual bruising or bleeding
    unusual tiredness or weakness
    Incidence not known:
    Abdominal or stomach pain
    diarrhea
    fainting
    fast, pounding irregular heartbeat or pulse
    glaucoma
    joint or muscle pain
    nausea
    numbness or tingling of face, hands, or feet
    redness and soreness of eyes
    swelling of feet or lower legs
    vomiting
    If any of the following symptoms of overdose occur while taking orphenadrine, get emergency help immediately:

    Symptoms of overdose:
    Blurred vision
    confusion, delirium, or hallucinations
    constipation
    difficult urination
    drowsiness
    dry eyes, mouth, nose, or throat
    eye pain
    flushing or redness of face
    troubled breathing
    Severity: Minor
    Some of the side effects that can occur with orphenadrine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Less common or rare:
    Dizziness or lightheadedness
    excitement, irritability, nervousness, or restlessness
    headache
    muscle weakness
    unusually large pupils of eyes
    Incidence not known:
    Anxiety
    deep or fast breathing with dizziness
    itching skin
    mental confusion
    numbness of feet, hands and around mouth
    trembling or shaking of hands or feet shakiness in legs, arms, hands, or feet
  • (oral tablet, extended release, injectable solution, compounding powder)