Diosmiplex (Vasculera) is a medical food for people with chronic venous insufficiency, a blood circulation disorder. Diosmiplex affects the function of blood vessels in the body.

Pramoxine is an anesthetic. It works by interfering with pain signals sent from the nerves to the brain.

Hydrocortisone is a steroid. It reduces the actions of chemicals in the body that cause inflammation.

Diosmiplex is a oral tablet you take by mouth. Diosmiplex, hydrocortisone, and pramoxine are combined into a cream to be applied to the rectum. The two forms of medicine are supplied in a kit that also contains cleansing wipes.

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  • Analpram Advanced
  • Stop using this medication and call your doctor at once if you have a serious side effect such as:

    severe burning, itching or irritation of the treated area; or
    rectal bleeding.
    Less serious side effects of diosmiplex / hydrocortisone / pramoxine topical may include:

    mild burning, itching, or dryness of the treated area.
    headache;
    mild skin rash;
    leg cramps;
    upset stomach; or
    swelling in your hands or feet.
  • (hydrocortisone acetate and pramoxine hydrochloride) cream