Amitriptyline is a tricyclic antidepressant. Chlordiazepoxide is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). These medicines affect chemicals in the brain that may be unbalanced in people with depression.

Amitriptyline and chlordiazepoxide is a combination medicine used to treat moderate to severe depression and anxiety.

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  • Limbitrol, Limbitrol DS
  • Severity: Moderate
    If any of the following side effects occur while taking amitriptyline / chlordiazepoxide, check with your doctor or nurse as soon as possible:

    Less common:
    Blurred vision or other changes in vision
    confusion or hallucinations (seeing, hearing, or feeling things that are not there)
    constipation
    difficulty in urinating
    eye pain
    fainting
    irregular heartbeat
    mental depression
    shakiness
    trouble in sleeping
    unusual excitement, nervousness, or irritability
    Rare:
    Convulsions (seizures)
    increased sensitivity to sunlight
    skin rash and itching
    sore throat and fever
    yellow eyes or skin
    Symptoms of overdose:
    Agitation
    confusion
    convulsions (seizures)
    dizziness or lightheadedness (severe)
    drowsiness (severe)
    enlarged pupils
    fast or irregular heartbeat
    fever
    hallucinations
    muscle stiffness or rigidity
    vomiting (severe)
    Severity: Minor
    Some of the side effects that can occur with amitriptyline / chlordiazepoxide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common:
    Bloating
    clumsiness or unsteadiness
    dizziness or lightheadedness
    drowsiness
    dryness of mouth or unpleasant taste
    headache
    weight gain
    Less common:
    Diarrhea
    nausea or vomiting
    unusual tiredness or weakness
    Side Effects: Post Treatment
    After you stop taking this drug, it is possible that you may still experience side effects that need medical attention. If you notice any of the following side effects check with your doctor immediately:

    Convulsions (seizures)
    headache
    increased sweating
    irritability or restlessness
    muscle cramps
    nausea or vomiting
    stomach cramps
    trembling
    trouble with sleeping, and vivid dreams
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