Amitiza (lubiprostone) increases the secretion of fluid in your intestines to help make it easier to pass stools (bowel movements).

Amitiza is used to treat chronic constipation, or constipation caused by opioid (narcotic) pain medicine. It may also be used to treat irritable bowel syndrome in women with constipation as the main symptom.

Amitiza is for use only in adults.

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  • Amitiza
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking lubiprostone:

    More common:
    Diarrhea
    full or bloated feeling or pressure in the stomach
    nausea
    stomach pain
    swelling of abdominal or stomach area
    Less common:
    Abdominal or stomach discomfort
    black, tarry stools
    blood in the stools
    chest discomfort or pain
    chills
    cold or flu-like symptoms
    cough
    difficult or labored breathing
    fever
    general feeling of discomfort or illness
    headache
    increased sweating
    joint pain
    loss of appetite
    loss of bowel control
    muscle aches and pains
    runny nose
    shivering
    shortness of breath
    sore throat
    sweating
    tightness in the chest
    trouble sleeping
    unusual tiredness or weakness
    vomiting
    Incidence not known:
    Abdominal or stomach tenderness
    difficulty with swallowing
    fainting
    fast, pounding, or irregular heartbeat or pulse
    hives
    puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    skin rash
    swelling
    If any of the following symptoms of overdose occur while taking lubiprostone, get emergency help immediately:

    Symptoms of overdose:
    Dry heaves
    dry mouth
    feeling of warmth
    lack or loss of strength
    paleness of the skin
    redness of the face, neck, arms, and occasionally, upper chest
    severe, unusual tiredness or weakness
    weight loss
    Severity: Minor
    Some of the side effects that can occur with lubiprostone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common:
    Excess air or gas in the stomach or intestines
    passing gas
    Less common:
    Acid or sour stomach
    belching
    bladder pain
    bloody or cloudy urine
    change in taste
    cold sweats
    difficult, burning, or painful urination
    difficulty with moving
    discouragement
    dizziness
    fear or nervousness
    feeling sad or empty
    frequent urge to urinate
    heartburn
    increased weight
    indigestion
    irritability
    loss of interest or pleasure
    loss of taste
    lower back or side pain
    muscle cramps
    muscle stiffness
    sore throat
    stomach upset
    swollen joints
    tingling of the hands or feet
    unusual drowsiness, dullness, tiredness, or feeling of sluggishness
  • (lubiprostone) capsule, gelatin coated