Ambrisentan prevents thickening of the blood vessels, especially those in the lungs and heart. Ambrisentan also lowers blood pressure in your lungs, helping your heart pump blood more efficiently.

Ambrisentan is used to treat pulmonary arterial hypertension (PAH). It improves your ability to exercise and prevents your condition from getting worse. Ambrisentan is sometimes used with a medicine called tadalafil (Adcirca).

Ambrisentan is available only from a certified pharmacy under a special program called LEAP (Letairis Education and Access Program). You must be registered in the program and sign agreements to use birth control and undergo pregnancy and blood testing.

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  • Letairis
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking ambrisentan:

    More common:
    Bloating or swelling of the face, arms, hands, lower legs, or feet
    rapid weight gain
    tingling of the hands or feet
    unusual weight gain or loss
    Less common:
    Cough
    fast, irregular, pounding, or racing heartbeat or pulse
    fever
    headache
    muscle aches
    pain or tenderness around the eyes and cheekbones
    sore throat
    stuffy or runny nose
    tightness of the chest
    trouble breathing
    unusual tiredness or weakness
    Incidence not known:
    Abdominal or stomach pain or tenderness
    chest pain
    clay colored stools
    dark urine
    decrease in the amount of urine
    decreased appetite
    dilated neck veins
    extreme fatigue
    irregular breathing
    large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
    loss of appetite
    nausea and vomiting
    noisy, rattling breathing
    pale skin
    skin rash, itching
    troubled breathing at rest
    troubled breathing with exertion
    yellow skin or eyes
    If any of the following symptoms of overdose occur while taking ambrisentan, get emergency help immediately:

    Symptoms of overdose:
    Blurred vision
    confusion
    dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
    sweating
    Severity: Minor
    Some of the side effects that can occur with ambrisentan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Less common:
    Difficulty having a bowel movement (stool)
    feeling of warmth
    redness of the face, neck, arms, and occasionally, upper chest
  • (oral tablet)