Aloxi (palonosetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Aloxi is used in adults to prevent nausea and vomiting caused by surgery, or by receiving medicine to treat cancer (chemotherapy).

Aloxi is used in children only to prevent nausea and vomiting caused by cancer medicine.

Aloxi is not for preventing nausea or vomiting that is caused by factors other than chemotherapy or surgery.

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  • Aloxi
  • Less common:
    Blurred vision
    chest pain or discomfort
    confusion
    difficult breathing
    dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
    fainting
    fever
    irregular heartbeats that continue
    sweating
    unusual tiredness or weakness
    Rare:
    Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
    extra heartbeats
    nervousness
    pain in the shoulders, arms, jaw, or neck
    pounding in the ears
    slow or fast heartbeat
    Incidence not known:
    Agitation
    diarrhea
    overactive reflexes
    poor coordination
    restlessness
    shivering
    talking or acting with excitement you cannot control
    trembling or shaking
    twitching
    If any of the following symptoms of overdose occur while taking palonosetron, get emergency help immediately:

    Symptoms of overdose:
    Bluish color of the fingernails, lips, skin, palms, or nail beds
    collapse
    gasping to breathe
    paleness of the skin
    seizures
    Severity: Minor
    Some of the side effects that can occur with palonosetron may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common:
    Difficulty having a bowel movement (stool)
    headache
    Less common:
    Acid or sour stomach
    belching
    bloated or full feeling
    blood in the urine
    bloody or black, tarry stools
    burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
    change in vision
    chills
    continuing ringing or buzzing
    cough
    decrease in frequency of urination
    decrease in urine volume
    deep breathing
    difficulty in passing urine
    drowsiness
    dry mouth
    excess air or gas in the stomach or intestines
    excessive sleeping
    eye irritation
    fear
    feeling happy
    feeling of warmth
    flushed dry skin
    fruit-like breath odor
    general feeling of discomfort or illness
    hearing loss
    heartburn
    hiccups
    impaired vision
    increased hunger
    increased thirst
    increased urination
    indigestion
    joint pain
    large, flat, blue or purplish patches in the skin
    loss of appetite
    muscle aches and pains
    muscle tremors
    numbness or tingling in the hands, feet, or lips
    painful knees and ankles
    painful urination
    passing gas
    raised red swellings on the skin, the buttocks, legs or ankles
    rash
    red, sore eyes
    redness of the face, neck, arms, and occasionally, upper chest
    runny nose
    sore throat
    stomach discomfort, upset, or pain
    sugar in the urine
    swelling or protruding veins
    trouble sleeping
    unexplained noise in the ears
    unexplained weight loss
    unusually deep sleep
    unusually long duration of sleep
    vein discoloration
    weakness or heaviness of the legs
  • (palonosetron hydrochloride) injection