Alosetron blocks the action of a chemical called serotonin in the intestines. This slows the movement of stools (bowel movements) through the intestines.

Alosetron is used to treat severe, chronic irritable bowel syndrome (IBS) in women who have had diarrhea as the main symptom for at least 6 months. Alosetron should be used only by women who have tried other IBS treatments without success. Alosetron has not been shown to be effective in men with IBS.

Alosetron is not a cure for irritable bowel syndrome. After you stop taking this medicine, your symptoms may return within 1 week.

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  • irritable bowel syndrome
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking alosetron:

    More common:
    Constipation
    Rare:
    Bloody diarrhea
    new or worsening stomach pain or discomfort
    rectal bleeding
    Incidence not known:
    Abdominal or stomach pain, cramping, or burning
    black, tarry stools
    diarrhea
    fever
    heartburn
    indigestion
    nausea
    vomiting with or without blood or material that looks like coffee grounds
    If any of the following symptoms of overdose occur while taking alosetron, get emergency help immediately:

    Symptoms of overdose:
    Clumsiness, unsteadiness, trembling, or other problems with muscle control or coordination
    convulsions (seizures)
    difficulty breathing
    shakiness and unsteady walk
    withdrawn or socially detached behavior
    Severity: Minor
    Some of the side effects that can occur with alosetron may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    Less common:
    Bleeding after bowel movement
    full or bloated feeling
    pressure in the stomach
    swelling of abdominal or stomach area
    uncomfortable swelling around rectal area
    Incidence not known:
    Headache
    skin rash
  • (oral tablet)