Estradiol is a form of estrogen, a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Estradiol transdermal skin patches are used to treat certain symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. This medicine is also used to prevent postmenopausal osteoporosis, or to treat ovarian disorders.

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  • Alora, Climara, Estraderm, Estradiol Patch, Menostar, Minivelle, Vivelle, Vivelle-Dot
  • Severity: Major
    You should check with your doctor immediately if any of these side effects occur when taking estradiol:

    Less common:
    Vaginal yeast infection
    Incidence not known:
    Change in vaginal discharge
    clear or bloody discharge from the nipple
    decrease in the amount of urine
    dimpling of the breast skin
    fast heartbeat
    fever
    hives, itching, or rash
    hoarseness
    inverted nipple
    irritation
    joint pain, stiffness, or swelling
    lump in the breast or under the arm
    noisy, rattling breathing
    pain or feeling of pressure in the pelvis
    pain, redness, or swelling in the arm or leg
    persistent crusting or scaling of the nipple
    redness of the skin
    redness or swelling of the breast
    sore on the skin of the breast that does not heal
    swelling of the eyelids, face, fingers, lips, hands, feet, or lower legs
    tightness in the chest
    troubled breathing at rest
    troubled breathing or swallowing
    vaginal bleeding
    If any of the following symptoms of overdose occur while taking estradiol, get emergency help immediately:

    Symptoms of overdose:
    Abdominal or stomach pain
    dizziness
    drowsiness
    nausea or vomiting
    tenderness of the breasts
    unusual tiredness or weakness
    Severity: Minor
    Some of the side effects that can occur with estradiol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

    More common:
    Back pain
    headache
    itching or pain of the vagina or genital area
    thick, white vaginal discharge with mild or no odor
    weight gain
    Less common:
    Body aches or pain
    chills
    cough
    diarrhea
    ear congestion
    loss of voice
    nasal congestion
    runny nose
    sneezing
    sore throat
    Incidence not known:
    Feeling sad or empty
    headache, severe and throbbing
    irritability
    lack of appetite
    tiredness
    trouble concentrating
    trouble sleeping
    welts
  • (estradiol) transdermal system, patch